“…Diacetyl (2,3-butanedione) is a natural byproduct of fermentation and known to be an important flavor compound in many food products. , It can be found in beer, wine, butter, cheese, milk, and yogurt. During the production of beer, diacetyl may impart a negative effect on beer flavor when it is above a certain concentration. , In lagers, its concentration is generally slightly lower than 0.10 mg L –1 , but it is usually higher in stouts and ales . It may also potentially cause diseases, including bronchiolitis obliterans syndrome, obliterative bronchiolitis, or impaired lung function, when the inhaled doses or exposure time increases. − Because of the potential undesirable effects of diacetyl on beer flavor and health safety, quantification of diacetyl in beer samples is critical for quality control and development of new beer products.…”