Analytical approaches to investigating metal-containing drugs

Harrington, Chris F.; Taylor, Andrew M.

doi:10.1016/j.jpba.2014.10.017

Cited by 13 publications

(5 citation statements)

References 26 publications

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“…The role of elemental speciation analysis in characterizing the interaction of metals and metalloids (and compounds containing such elements) with biological systems has been the subject of several reviews. Harrington and Taylor 17 discussed analytical approaches to investigating two "metal"-containing drugs, having rst surveyed the more general need for the measurement of potentially harmful elements in biological uids or tissues arising from the use of dietary supplements and toiletries as well as the consumption of active pharmaceutical ingredients (APIs). The two APIs highlighted are 4-(N-(Sglutathionylacetyl)amino) phenylarsenoxide (GSAO), which is under investigation for the treatment of solid tumours, and cisdiamminedichloroplatinum(II) (cisplatin), which is widely used for treatment of testicular, ovarian, bladder, head and neck cancers.…”

Section: Topical Reviewsmentioning

confidence: 99%

Atomic Spectrometry Update: review of advances in elemental speciation

Clough

Harrington

Hill

et al. 2016

J. Anal. At. Spectrom.

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Section: Topical Reviewsmentioning

confidence: 99%

Atomic Spectrometry Update: review of advances in elemental speciation

Clough

Harrington

Hill

et al. 2016

J. Anal. At. Spectrom.

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“…Also, carboplatin is the most effective one for the treatment of retinoblastoma and plays a key role in all retinoblastoma therapeutic schedules . It is considered that cell growth inhibition of carboplatin can be achieved by forming intracellular platinum complexes that bind to DNA and then producing both inter‐ and intra‐strand crosslinks to inhibit DNA replication, RNA transcription, as well as protein synthesis .…”

Section: Introductionmentioning

confidence: 99%

“…bind to DNA and then producing both inter-and intra-strand crosslinks to inhibit DNA replication, RNA transcription, as well as protein synthesis [1,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A novel and fully validated hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of intact carboplatin in human plasma

Ren

Qin

Fan

et al. 2018

Separation Science Plus

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Carboplatin is an anticancer drug widely used to treat a variety of cancers. However, a simple, sensitive and rapid method for the quantitation of intact carboplatin is still absence for therapeutic drug monitoring or clinical trials. In this work, a rapid, universal, and reliable hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of intact carboplatin in human plasma was developed and fully validated. Carboplatin was extracted from human plasma by simple protein precipitation with acetonitrile. A good chromatographic separation of carboplatin was achieved on a Waters XBridge HILIC column (2.1 × 150 mm, 3.5 μm), with the analytical time 5.5 min for one sample. The linearity range of the assay was from 10 to 2000 ng/mL. The method was linear (r2 > 0.9989), accurate (<6% bias, 12% bias at LOQ) and precise (intra‐day and inter‐day precision of <3% coefficient of variation). The stability of intact carboplatin in human plasma with three different anticoagulants was assessed in this study. Furthermore, the matrix effect of hemolysis and hyperlipidemic samples was also evaluated for the first time. This work made the routine determination of intact carboplatin feasible and universal in clinical practice.

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“…Numerous analytical methodologies have been developed in the last decades for the determination of cisplatin [13,14]. However, quantitative determination of MHC is scarcely reported due to the lack of a pure standard of MHC.…”

Section: Introductionmentioning

confidence: 99%

“…These non-selective techniques include phosphorescence [18], X-ray fluorescence [19], atomic absorption spectroscopy (AAS) [20][21][22] and inductively coupled plasma-mass spectrometry (ICP-MS) [23][24][25]. ICP-MS is the most frequently used tool for the measurement of total platinum for the drug cisplatin [14,26]. However, circulating total platinum represents a mixture of platinum species, with differing biological activity and toxicity profiles.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic hydrophilic interaction liquid chromatography-tandem mass spectrometry with HybridSPE-precipitation for the determination of intact cisplatin in human plasma

Xie

Colin

Bocxlaer

2017

Talanta

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Cisplatin is a first-line chemotherapeutic for the treatment of a wide variety of cancers since its discovery in the 1960s. Although various techniques have been reported for the measurement of total platinum in biological matrices, such as inductively coupled plasma-mass spectrometry and derivatization procedures, a specific, sensitive and robust assay for the quantification of intact cisplatin is still lacking. Therefore, we present a rapid, selective, sensitive, and reliable UHPLC-MS/MS based method for the determination of intact cisplatin in human plasma in support of a Phase II clinical trial. The optimal chromatographic behavior of cisplatin was achieved on a Syncronis HILIC column (50 × 2.1mm, 1.7µm, zwitterionic stationary phase). The retention behavior of cisplatin on this zwitterion-based stationary phase was well described by an adsorptive interaction model. A simple sample preparation based on protein precipitation combined with the removal of phospholipids by HybridSPE-precipitation was developed. The method was proven to be free of a relative matrix effect. The assay was validated within a range of 20 - 10,000ng/mL using 100μL of plasma sample. The intra and inter-day precisions were all less than 7.6%, and none of the bias was greater than 13.1%, thus corroborating that the developed method is precise and accurate. As a proof of concept, the assay has been successfully applied to plasma samples obtained from different patients who were enrolled in the Phase II trial and were treated with cisplatin.

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Analytical approaches to investigating metal-containing drugs

Cited by 13 publications

References 26 publications

Atomic Spectrometry Update: review of advances in elemental speciation

Atomic Spectrometry Update: review of advances in elemental speciation

A novel and fully validated hydrophilic interaction liquid chromatography with tandem mass spectrometry method for the determination of intact carboplatin in human plasma

Zwitterionic hydrophilic interaction liquid chromatography-tandem mass spectrometry with HybridSPE-precipitation for the determination of intact cisplatin in human plasma

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