Analytical approaches for the determination of deferiprone and its iron (III) complex: Investigation of binding affinity based on liquid chromatography-mass spectrometry (LC-ESI/MS) and capillary electrophoresis-frontal analysis (CE/FA)

Quality by design approach for green HPLC method development for simultaneous analysis of two thalassemia drugs in biological fluid with pharmacokinetic study

“…8,9 By surveying the literature review of these drugs, it was found that numerous methods have been reported for the detection of DFX alone in bulk or in its pharmaceutical formulation or in biological uids, including spectrophotometric [10][11][12] and HPLC [13][14][15][16][17][18][19][20][21][22][23][24] methods. Additionally, DFP was determined alone either in bulk or in human plasma by different methods like spectrophotometric, [25][26][27] spectro-uorimetric, 28 HPLC, [29][30][31][32][33][34] capillary zone electrophoresis, 34 and electrochemical 35,36 methods. There were only two published voltammetric methods for determining the two proposed drugs simultaneously.…”

Sensitivity enhancement of capillary electrophoresis‐frontal analysis‐based method for characterization of drug‐protein interactions using on‐line sample preconcentration

“…Further, the optimization of the volume of injected interaction mixture given by injection time and pressure was performed. Taking into account previous experience with CE-FA [4,7,10,35,36] and recommendations from the literature [5,37], hydrodynamic injection was used. Then, the HSA concentration used for the interaction study was optimized since the change in plateau heights between the drug without protein and the drug with protein is important for evaluating results.…”

Oxytetracycline-derived carbon dots as a fluorescent switch in trace ferric ion sensing

“…We also drew the I 0 /I B c Fe(III) and I/I 0 B c Fe(III) curves according to eqn (11), and predicted the trend of the corresponding curves under different fluorophore concentrations [*] 0 and reaction equilibrium constant K values, as shown in Fig. 7b and c.…”

“…The U.S. Environmental Protection Agency (EPA) has regulated the maximum allowable level of Fe(III) in drinking water to be 0.3 mg L À1 (equivalent to 5.4 mM). 7,8 Among the available trace analysis methods for Fe(III), fluorescence technology exhibits greater advantages in terms of rapidness, convenience and economics, but not always in sensitivity (dQE/dc Fe(III) , QE = quenching efficiency), selectivity, safety and adaptability, when compared to mass spectrometry (MS), 9 voltammetry, 10 liquid chromatography (LC), 11 and atomic absorption spectroscopy (AAS). 12 Carbon dots (CDs) are nextgeneration photoluminescent nanomaterials that provide remarkable fluorescence properties, 13 with less toxicity, 14,15 better biocompatibility 16,17 and lower cost.…”