Analytical approach to the reaction cross section of the fusion of protons with boron isotopes aimed at cancer therapy

Geser, Federico Alejandro; Valente, M.

doi:10.1016/j.apradiso.2019.04.034

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…The FLUKA code (version 2020.0.4) accurately models the interaction and transport of ions, electrons, photons, and neutrons from energies related to the physics of particles down to a few keV. FLUKA is continuously being benchmarked with models and experimental data concerning nuclear cross sections, including the proton-boron fusion reactions [31,32]. For low-energy protons, the most probable channel for α-particle production is a sequential decay via 8 Be in its fundamental or excited state:…”

Section: Proton Energies and α-Particle Sourcesmentioning

confidence: 99%

Energetic α -particle sources produced through proton-boron reactions by high-energy high-intensity laser beams

et al. 2021

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Section: Proton Energies and α-Particle Sourcesmentioning

confidence: 99%

Energetic α -particle sources produced through proton-boron reactions by high-energy high-intensity laser beams

et al. 2021

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“…Finally, Monte-Carlo (MC) codes, like FLUKA [71] or GEANT4 [72], can model the interaction and the transport of ions, electrons, photons and neutrons. FLUKA is continuously benchmarked against models and experimental data of nuclear cross sections and specifically the pB fusion reaction [73].…”

Section: Challenge On Development On Adapted Numerical Simulation Toolsmentioning

confidence: 99%

Perspectives on research on laser driven proton-boron fusion and applications

Batani

2023

J. Inst.

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Recent experiments with high-intensity lasers have shown record production of α-particles by irradiating boron-hydrogen targets. This opened the way to completely new studies on proton-boron fusion with multiple goals: i) studies related to nuclear fusion. The proton-boron fusion reaction produces 3 α-particles and releases a large energy. It is considered an interesting alternative to deuterium-tritium fusion because it produces no neutrons, therefore no activation and radioactive wastes. ii) generation of novel laser-driven α-particle sources. Laser-driven α-particle sources are promising for their potential high brightness while remaining compact. They could be used for multidisciplinary applications, including medical ones. The COST Action CA21128 — PROBONO (PROton BOron Nuclear fusion: from energy production to medical applicatiOns) is the first international programme which aims at understanding the physics involved in laser-driven pB fusion, including the study of Equation of State of boron and boron compounds. Action's goals are to facilitate access to experimental infrastructures, maximize production of new knowledge, boost the career of young researchers by fostering opportunities for training, and finally interconnect researchers across countries building a well-organized community focused on pB research.

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“…Experimental results clearly indicate that the protonboron nucleus reaction is a nuclear reaction resulting in the production of three alpha particles having low energy (less than 4 MeV) and, as a result, high linear energy transfer (high-LET) [12,13]. The probability of this reaction increases around the Bragg peak leading to an increase in the absorbed dose at this depth [14,15]. Cross section of this reaction is shown in figure 1 [16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of different concentrations of boron on proton therapy of the liver using GEANT4 Monte Carlo toolkit

2022

ijp

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Experimental results have shown that dadding boron to tumor tissue during proton therapy increases the mortality of cancer cells. This work has investigated how to form a spread-out Bragg peak in the proton therapy of a liver-located tumor by simulating the MIRD phantom and designing a range modulator. The simulations were carried out using a GEANT4 Monte Carlo toolkit. Also, the absorbed dose of the different organs near the liver was determined via simulations. To study the effect of boron on liver proton therapy, a tumor impregnated with different percentages of boron was simulated and the effect of energy released in the tumor as a result of alpha particles, protons and their combinations was investigated. The absorbed dose in the tumor at different proton energies and with varying percentages of boron was investigated. It was found that the absorbed dose in the tumor increases by adding boron, however; it decreases by increasing the energy from a certain limit (~80 MeV) of more than 60% boron.

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Analytical approach to the reaction cross section of the fusion of protons with boron isotopes aimed at cancer therapy

Cited by 8 publications

References 16 publications

Energetic α -particle sources produced through proton-boron reactions by high-energy high-intensity laser beams

Energetic α -particle sources produced through proton-boron reactions by high-energy high-intensity laser beams

Perspectives on research on laser driven proton-boron fusion and applications

Evaluation of the effect of different concentrations of boron on proton therapy of the liver using GEANT4 Monte Carlo toolkit

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