Analytical and Clinical Evaluation of Troponin I Determination on Dimension RXL-HM

Häfner, Gerd; Peetz, D.; Dati, Francesco; Post, Felix; Blankenberg, Stefan; Aa, Peivandi; Sucké, Bernd; Hj, Rupprecht; Dahm, Manfred; R, von Kleist; Prellwitz, W.

doi:10.1515/cclm.2000.051

Cited by 20 publications

(13 citation statements)

References 23 publications

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“…By contrast, the first-generation troponin I assays (e.g., the investigated Stratus II assay) had a limited sensitivity and were not able to detect minor myocardial injury. Currently, several new sensitive TnI assays are available opening the opportunity to reevaluate the value of TnI in CRF patients [24][25][26]. The TnI (ACS:180) assay investigated was one of the first new sensitive assays showing a much better sensitivity to predict the outcome than the Stratus II assay [26].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Troponin T,Troponin I, and CK-MBmass in Patients with Chronic Renal Failure

Peetz¹,

Schütt²,

Sucké³

et al. 2003

Medizinische Klinik

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Troponin T,Troponin I, and CK-MBmass in Patients with Chronic Renal Failure

Peetz¹,

Schütt²,

Sucké³

et al. 2003

Medizinische Klinik

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“…To allow clotting, the samples were kept at room temperature for 15 min, then centrifuged, and stored as serum aliquots at -20 ° C until all blood samples were obtained. cTnI concentrations were determined using a heterogeneous immunoassay module (RxL-HM, Dade Behringer) [12] . The lower limit of detection for cTnI is 0.04 g/l (value declared by the manufacturer).…”

Section: Methodsmentioning

confidence: 99%

Cardiac Troponin I in Asphyxiated Neonates

Trevisanuto¹,

Picco²,

Golin³

et al. 2006

Neonatology

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Background: Cardiac troponins T (cTnT) and I (cTnI) are well-established markers in detecting myocardial ischemic damage in adults. Perinatal asphyxia is associated with cardiac dysfunction. Objectives: To evaluate serum concentrations of cTnI in asphyxiated neonates and to investigate whether cTnI is correlated with the traditional markers of asphyxia. Methods: Blood samples were collected from 13 asphyxiated neonates (umbilical artery pH <7.18 and either a 1-min Apgar score <4 or a 5-min Apgar score <7) and 39 controls. Data on gestation, birth weight, sex, Apgar scores, mode of delivery, umbilical pH, creatinine, serum activity of aspartate and alanine aminotransferase, and QTc interval were investigated. Results: Median (range) cTnI concentrations were significantly higher in asphyxiated neonates with respect to healthy infants: 0.36 µg/l (0.05–11) versus 0.04 µg/l (0.04–0.06); p < 0.01. In asphyxiated babies, no statistically significant correlations were found between concentrations of cTnI and the other markers of asphyxia. Conclusions: In asphyxiated neonates, cTnI concentrations are higher with respect to healthy infants, suggesting the presence of myocardial damage in this group of high-risk patients. cTnI does not correlate with the traditional markers of asphyxia.

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“…10,12 Based on the data published so far, a clear statement about this phenomenon is not possible. In our opinion, cTnI release most likely reflects normal turnover of myocytes under physiologic conditions.…”

Section: Cardiac Troponin I Release In Healthy Volunteersmentioning

confidence: 99%

Serial analysis of troponin I levels in patients with ischemic and nonischemic dilated cardiomyopathy

Nellessen

Goder

Schobre

et al. 2006

Clinical Cardiology

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SummaryBackground: Ongoing myocardial cell damage forms the basis for progression of chronic heart failure. Evidence is accumulating that progressive loss of cardiac myocytes is associated with the release of cardiac troponin I (cTnI).Hypothesis: This study sought to determine whether levels of cTnI are of prognostic value for risk stratification of patients with chronic heart failure.Methods: Release of cTnI was measured by conventional enzyme immunoassay following serum ultrafiltration in 58 consecutive patients hospitalized for chronic heart failure and 31 healthy volunteers serving as control group. Determination of serum levels was performed every 2 weeks over a time interval of 3 months. According to the results of coronary angiography, patients were divided into Group D showing normal coronary arteries (n = 33, ejection fraction 27 ± 6.1%) and Group I showing severe coronary heart disease (n = 25, ejection fraction 28.8 ± 7.8%). Survival of patients was evaluated after a mean time interval of 3 years.Results: The mean cTnI serum level over all measurements was 0.66 ± 1.8 ng/ml in patients versus 0.11 ± 0.48 ng/ml in volunteers. At all six points of analysis, the mean cTnI serum level was significantly different (p < 0.001) between patients and volunteers. There was no significant difference between patients with and without coronary heart disease following hospital discharge, however, troponin release was significantly different between survivors and nonsurvivors (n = 27) (0.56 ng/ml vs. 0.84 ng/ml; p < 0.05).

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Analytical and Clinical Evaluation of Troponin I Determination on Dimension RXL-HM

Cited by 20 publications

References 23 publications

Prognostic Value of Troponin T,Troponin I, and CK-MBmass in Patients with Chronic Renal Failure

Prognostic Value of Troponin T,Troponin I, and CK-MBmass in Patients with Chronic Renal Failure

Cardiac Troponin I in Asphyxiated Neonates

Serial analysis of troponin I levels in patients with ischemic and nonischemic dilated cardiomyopathy

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