Analyte Flux at a Biomaterial-Tissue Interface over Time: Implications for Sensors for Type 1 and 2 Diabetes Mellitus

Ekberg, Neda Rajamand; Brismar, Kerstin; Malmstedt, Jonas; Hedblad, Mari‐Anne; Adamson, Ulf; Ungerstedt, Urban; Wisniewski, Natalie A.

doi:10.1177/193229681000400505

Cited by 7 publications

(8 citation statements)

References 47 publications

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“…Profound differences between rats and humans in the FBR and flux of various metabolites in the interstitial fluid at the sensor-tissue interface have been demonstrated over 8 days of SubQ implantation. 118,119 To relate the choice of animal models with physiological differences to biomechanical forces acting on the sensortissue interface, we consider several factors. First, the SubQ muscle layer that exists in furry animals will be a source of repetitive micromotion.…”

Section: Animal Modelmentioning

confidence: 99%

Biomechanics of the Sensor-Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and the Foreign Body Response—Part I: Theoretical Framework

Helton

Ratner

Wisniewski

2011

J Diabetes Sci Technol

110

113

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The importance of biomechanics in glucose sensor function has been largely overlooked. This article is the first part of a two-part review in which we look beyond commonly recognized chemical biocompatibility to explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I provides a theoretical framework to describe how biomechanical factors such as motion and pressure (typically micromotion and micropressure) give rise to interfacial stresses, which affect tissue physiology around a sensor and, in turn, impact sensor performance. Three main contributors to sensor motion and pressure are explored: applied forces, sensor design, and subject/patient considerations. We describe how acute forces can temporarily impact sensor signal and how chronic forces can alter the foreign body response and inflammation around an implanted sensor, and thus impact sensor performance. The importance of sensor design (e.g., size, shape, modulus, texture) and specific implant location on the tissue response are also explored. In Part II: Examples and Application (a sister publication), examples from the literature are reviewed, and the application of biomechanical concepts to sensor design are described. We believe that adding biomechanical strategies to the arsenal of material compositions, surface modifications, drug elution, and other chemical strategies will lead to improvements in sensor biocompatibility and performance.

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Section: Animal Modelmentioning

confidence: 99%

Biomechanics of the Sensor-Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and the Foreign Body Response—Part I: Theoretical Framework

Helton

Ratner

Wisniewski

2011

J Diabetes Sci Technol

110

113

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“…For example, l -Lactate is an analyte of great interest due to its role in sports medicine [ 5 ], clinical chemistry [ 6 ], the food processing industry [ 7 ], and overall normal metabolic function. While lactate is a normal byproduct of cellular metabolism, intracellular concentrations of lactate increase more dramatically during anaerobic respiration; likewise, interstitial lactate levels increase as it is excreted by cells, and it can accumulate in muscles and other tissues to cause soreness, pain, and impaired function [ 8 , 9 ]. Therefore, lactate can be used to assess a variety of acute deoxygenation events including hypovolemia (shock) [ 10 ], heart disease [ 11 ], and renal failure [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Lactate Sensors Based on Lactate Oxidase and Palladium Benzoporphyrin Immobilized in Hydrogels

et al. 2015

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An optical biosensor for lactate detection is described. By encapsulating enzyme-phosphor sensing molecules within permeable hydrogel materials, lactate-sensitive emission lifetimes were achieved. The relative amount of monomer was varied to compare three homo- and co-polymer materials: poly(2-hydroxyethyl methacrylate) (pHEMA) and two copolymers of pHEMA and poly(acrylamide) (pAam). Diffusion analysis demonstrated the ability to control lactate transport by varying the hydrogel composition, while having a minimal effect on oxygen diffusion. Sensors displayed the desired dose-variable response to lactate challenges, highlighting the tunable, diffusion-controlled nature of the sensing platform. Short-term repeated exposure tests revealed enhanced stability for sensors comprising hydrogels with acrylamide additives; after an initial “break-in” period, signal retention was 100% for 15 repeated cycles. Finally, because this study describes the modification of a previously developed glucose sensor for lactate analysis, it demonstrates the potential for mix-and-match enzyme-phosphor-hydrogel sensing for use in future multi-analyte sensors.

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“…However, they require specific instruments, time and qualified people to ensure the quality and reproducibility of the results. Therefore, some authors proposed another strategy: implanting an external device into the patient’s body [ 273 ]. This would allow the real-time analysis of the metabolite set of interest.…”

Section: Impact Of Metabolomics In the Field Of Obesity Type II Dmentioning

confidence: 99%

“…However, the presence of a foreign material could induce a pro-inflammatory process and therefore alter the concentrations of some metabolites of interest. By using microdialysis to model implanted sensors, the study demonstrated that glucose, lactate and urea concentrations rise over time following implantation [ 273 ]. This has been associated with the pro-inflammatory response induced by the implanted capillary.…”

Section: Impact Of Metabolomics In the Field Of Obesity Type II Dmentioning

confidence: 99%

“…This has been associated with the pro-inflammatory response induced by the implanted capillary. However, increased levels were also found for other metabolites, such as glycerol and pyruvate, retrieved at high concentrations in T2DM patients [ 273 ]. This confirms the possibility of real-time screening of some metabolites of interest in patients, thus allowing rapid treatment when necessary.…”

Section: Impact Of Metabolomics In the Field Of Obesity Type II Dmentioning

confidence: 99%

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Unraveling Biochemical Pathways Affected by Mitochondrial Dysfunctions Using Metabolomic Approaches

et al. 2014

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Mitochondrial dysfunction(s) (MDs) can be defined as alterations in the mitochondria, including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and the mitochondrial accumulation of protein aggregates. All these MDs are known to alter the capacity of ATP production and are observed in several pathological states/diseases, including cancer, obesity, muscle and neurological disorders. The induction of MDs can also alter the secretion of several metabolites, reactive oxygen species production and modify several cell-signalling pathways to resolve the mitochondrial dysfunction or ultimately trigger cell death. Many metabolites, such as fatty acids and derived compounds, could be secreted into the blood stream by cells suffering from mitochondrial alterations. In this review, we summarize how a mitochondrial uncoupling can modify metabolites, the signalling pathways and transcription factors involved in this process. We describe how to identify the causes or consequences of mitochondrial dysfunction using metabolomics (liquid and gas chromatography associated with mass spectrometry analysis, NMR spectroscopy) in the obesity and insulin resistance thematic.

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Analyte Flux at a Biomaterial-Tissue Interface over Time: Implications for Sensors for Type 1 and 2 Diabetes Mellitus

Cited by 7 publications

References 47 publications

Biomechanics of the Sensor-Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and the Foreign Body Response—Part I: Theoretical Framework

Biomechanics of the Sensor-Tissue Interface—Effects of Motion, Pressure, and Design on Sensor Performance and the Foreign Body Response—Part I: Theoretical Framework

Characterization of Lactate Sensors Based on Lactate Oxidase and Palladium Benzoporphyrin Immobilized in Hydrogels

Unraveling Biochemical Pathways Affected by Mitochondrial Dysfunctions Using Metabolomic Approaches

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