Analysis the Role of Oxygen, Light Intensity, Threshold Dose and Efficacy Improvement of Anti-Cancer via Type-II Photodynamic Therapy

Lin, J. T.; Chen, Kuo Ti; Liu, Hsia Wei

doi:10.31031/nacs.2018.02.000533

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Resupply of PS or oxygen during the light exposure would enhance the overall efficacy. This new strategy has been proposed in type-I corneal crosslinking by Lin [29] and type-II anti-cancer by Lin et al [35].…”

Section: Numerical Resultsmentioning

confidence: 99%

Modeling the Dynamic Concentration Profiles and Efficacy of Type-I and Type-II Photopolymerization

J¹,

Cheng²,

Chen³

et al. 2018

Preprint

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The kinetics and efficacy profiles of photoinitiated polymerization are theoretically presented. For the same dose, lower light intensity achieves a higher steady-state-efficacy (SSE) in type-I; in contrast, type-II has an equal SSE. Higher light intensity has a faster rising efficacy, due to faster depletion of photoinitiator (PS) concentration. However, type-II process is also affected by the available oxygen. Higher light intensity produces more efficient singlet oxygen, resulting a higher transient efficacy, in which all intensities reach the same SSE when oxygen is completely depleted. With external oxygen, type-II efficacy increases with time, otherwise, it is governed only by the light dose, i.e., same dose achieves same efficacy. Moreover, type-II has an efficacy follows Bunsen Roscoe law (BRL), whereas type-I follows non-BRL. The measured type-I efficacy and gelation profile are analyzed by our analytic formulas. Schematics of the photocrosslinking stage defined by the availability of oxygen is developed, where both type-I and –II coexist until the oxygen is depleted. The overall efficacy may be enhanced by resupply of PS or oxygen during the light exposure. The roles of light dose and PS concentration on the efficacy of photoinitiated polymerization should be are governed a new concept of a volume efficacy (Ve), defined by the product of the crosslink (or gelation) depth (CD) and local [efficacy].

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Section: Numerical Resultsmentioning

confidence: 99%

Modeling the Dynamic Concentration Profiles and Efficacy of Type-I and Type-II Photopolymerization

J¹,

Cheng²,

Chen³

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…We have also presented the improvement of anti-cancer efficacy by synergistic effects of PDT and photothermal therapy (PTT) [16][17][18]. The role of concentration of PS and oxygen, rate constant, oxygen external source term, light dose, intensity and exposure time in the efficacy and threshold dose of anti-cancer was theorized [12] and a drug-light dose law was also analyzed for optimal PS concentration [13]. In this study, we will focus the measured profiles of the cell viability (measured in vitro) for various light intensities and PS concentrations, which will be analyzed by our developed formulas and numerical modeling.…”

Section: Introductionmentioning

confidence: 99%

Empirical Modeling of Cancer Cell Viability in Oxygen-Mediated Photodynamic Therapy

Chen¹,

Lin²,

Liu³

2019

J Cancer Sci Clin Ther

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The dynamic roles of photosensitizer (PS) concentration and light intensity were measured and analyzed empirically. The efficacy of photodynamic therapy (PDT) and cell viability (CV) are measured (in vitro) and analyzed by analytic and numerical modeling. For a fixed PS concentration, CV is a nonlinear deceasing function of light intensity and exposure time; for a fixed light intensity, higher PS concentration achieves higher efficacy or smaller CV (at steady-state), in consistent to our analytic formulas. The anticancer efficacy may be improved by various strategies such as resupply of Ce6, external oxygen, or stabilizing the singlet oxygen (with increased lifetime).

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Analysis the Role of Oxygen, Light Intensity, Threshold Dose and Efficacy Improvement of Anti-Cancer via Type-II Photodynamic Therapy

Cited by 2 publications

References 8 publications

Modeling the Dynamic Concentration Profiles and Efficacy of Type-I and Type-II Photopolymerization

Modeling the Dynamic Concentration Profiles and Efficacy of Type-I and Type-II Photopolymerization

Empirical Modeling of Cancer Cell Viability in Oxygen-Mediated Photodynamic Therapy

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