Analysis, physiological and clinical significance of 12-HETE: A neglected platelet-derived 12-lipoxygenase product

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A 2 -IIA

“…Interestingly, collagen-induced platelet MPs dominantly produced 12(S)-HETE, consistent with the reported activation of 12-LO through the immunoreceptor-based activation motif-containing the FcRγ chain involved in collagen signaling (57). 12(S)-HETE is a too-often neglected mediator, and its exact clinical significance remains a matter of debate (58). It is thought to be involved in the reorganization of the actin cytoskeleton (59), hypertension (60), angiogenesis, and cancer (61).…”

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

“…Studies on INS-1E beta cells that were incubated with high levels of glucose and analysis of plasma of hyperglycemic Psammomys obesus gerbils showed increased levels of 4-HNE (Cohen et al, 2011). This seems due to the presence of leukocytetype 12/15-LO that generates in rodents both 12 -HETE and 15-HETE (Burger et al, 2000;Porro et al, 2014).…”

“…Leukocyte-type 12/15-LO produces both 12-HpETE and 15-HpETE in mice, whereas 15-LO and 12-LO in human produce 15-HpETE and 12-HpETE, respectively (Burger et al, 2000;Porro et al, 2014). GPx transforms these hydroperoxy metabolites (see below) to the respective12-HETE, 15-HETE [and the linoleic acidderived 13-HODE (Spiteller et al, 2001)], which can interact with specific cell surface G-protein-coupled receptors and/or activate members of the PPAR family to induce gene transcription (Porro et al, 2014;Powell and Rokach, 2015).…”

Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA2 Signaling Pathway

“…The reverse was observed for simvastatin and dLGG treatments where LXA 4 levels were increased. 8-, 12-, 15-HETE, and the downstream metabolites have systemic anti-and prothrombotic activities (33)(34)(35). They are also involved in pulmonary vascular smooth muscle remodeling and apoptosis (36)(37)(38), but complete understanding of the physiological roles of these metabolites cascades leading to the production of leukotoxins including HODEs and EpOMEs (31).…”