Analysis On Short-Term Change of Macular Function and The Correlates After Intravitreal Conbercept for CRVO-ME

Abstract

•AIM: To study the short-term change of macular function and the correlates after intravitreal conbercept for CRVO-ME•STUDY DESIGN: Prospective,clinical study.•METHODS: 23 patients(23 eyes) were recruited, who were non-ischemia central retinal vein occlusion dianosed by FFA (fundus fluorescein angiography) and treated with intravitreal conbercept for macular edema. best - corrected visual acuity ( BCVA ),central macular thickness(CMT), amplitude density of P1 wave and implicit time of P1,N1 wave from ring 1 and ring 2 of mf-ERG were measured before and 1week、2month after treatment.•RESULTS: Compared to the baseline, BCVA、CMT、amplitude density of P1 wave and implicit time of P1,N1 wave from ring 1 and ring 2 were greatly improved at 1W、2M after treatment; better results were gained at 2M compared to 1W; Pearson correlation analysis shows no significantly correlation between the improvement of mf-ERG with the change of BCVA、CMT.•CONCLUSION: The BCVA、the strcture and the function of macular were greatly improved after intravitreal conbercept for central retinal vein occlusion induced macular edema; therefore no significantly correlation between the improvement of the function of macular with the strcture of macular and BCVA.