Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure

Abstract

In the coming decades human space exploration is expected to move beyond low-Earth orbit. This transition involves increasing mission time and therefore an increased risk of radiation exposure from solar particle event (SPE) radiation. Acute radiation effects after exposure to SPE radiation are of prime importance due to potential mission-threatening consequences. The major objective of this study was to characterize the dose–response relationship for proton and γ radiation delivered at doses up to 2 Gy at high (0.5 Gy/min) and low (0.5 Gy/h) dose rates using white blood cell (WBC) counts as a biological end point. The results demonstrate a dose-dependent decrease in WBC counts in mice exposed to high- and low-dose-rate proton and γ radiation, suggesting that astronauts exposed to SPE-like radiation may experience a significant decrease in circulating leukocytes.

Evaluation the Effect of Low Dose Ionizing Radiation on Radiological Staff

“…White blood cells are the most sensitive to gamma in the long-term effect (Sanzari et al, 2013).Reduction in blood cell counts in a dose-dependent manner but WBCs are less dependent (Maks et al, 2011) In the current study,we found strong liner correlation between peripheral blood count and liver enzyme with quarter accumulationdose, knowing that we ignore the results of all employees who have received a small radiation dose (< 0.1 mSv) in the last three months.the correlation is strong positive for RBCs (R= 0.9), WBCs (R= 0.995) and SGOT liver enzyme (R=0.934) but moderate negative for platelets count (R= -0.569) and positive for SGPT liver enzyme (0.309).…”

“…In contrast, platelets decline more gradually, over a longer time period (Maks et al, 2011; The aim of the present study is to evaluate low dose ionizing radiation effect on RBCs, WPCs, Platelets and liver enzyme in radiology staff…”

Evaluation the Synergistic Effect of High Dose Radiation of Radioiodine on the Immune System Suppressed By Cyclosporine

“…That the results can help people exposed to these radiations, such astronauts exposed to cosmic radiation and Gamma (γ) radiation, which can cause a significant decrease in white blood cells and immunosuppression (Maks et al, 2011).…”

Radiation Dose-Rate Effects on Select Biomarkers in a Mouse Total-Body Irradiation Model

“…There is no significant doserate effect of gamma irradiation on circulating erythrocytes and leukocytes when comparing high and low dose-rates [21][22][23][24], although the latter low doserates are far lower than the ones investigated herein. However, there is a dose-rate effect on thrombocytes [23], and low dose-rate irradiation significantly decreases leukocytes, erythrocytes and WBCs in a dosedependent fashion [21][22][23]. Radiation accidents and studies related to the space program provide the most information regarding the effect of low dose-rate irradiation on CBC values.…”

“…Gammairradiation is often compared with high LET irradiations in these studies. It has been shown that there is no significant dose-rate effect of gamma irradiation on circulating erythrocytes and leukocytes when comparing high and low dose-rates [21][22][23], although the low dose-rates are lower than the ones used here. However, there is a dose-rate effect on thrombocytes [23] and low dose-rate irradiation significantly decreases leukocytes, erythrocytes and WBCs in a dose-dependent fashion [21][22][23].…”