Analysis of Volatile Compounds in Radix Bupleuri Injection by GC–MS–MS

Liu, Suhong; Lu, Sensen; Su, Yue; Guo, Yinlong

doi:10.1007/s10337-011-2082-7

Cited by 12 publications

(8 citation statements)

References 42 publications

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“…[1][2][3][4] Qualitative approaches comprising mass spectral search, retention index and diversified scan technologies were utilized to identify volatile compounds. [5][6][7][8] The combination of these approaches can provide satisfactory identification results for volatile compounds including some trace-level components. However, the rapid development and wide application of high-resolution-timeof-flight-mass spectrometry (HR-ToF-MS) in the last decade allows us to look at the qualitative problem from a different point of view.…”

Section: European Journal Of Mass Spectrometrymentioning

confidence: 99%

Application of Gas Chromatography-Quadrupole-Time-of-Flight-Mass Spectrometry for Post-Target Analysis of Volatile Compounds in Fructus Amomi

Kang

Zhang

et al. 2013

Eur J Mass Spectrom (Chichester)

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A post-target analysis method based on gas chromatography coupled to a high-resolution quadrupole time-of-flight mass analyzer is applied for the investigation of volatile compounds in Fructus Amomi. A series of narrow window extracted ion chromatograms at selected characteristic ions were performed. Chromatographic peaks with the same retention time in different extracted ion chromatograms was used to screen out the candidate compound. Identification was achieved by the accurate masses of several characteristic ions and the retention index of the peak. Forty six compounds, including 12 monoterpene compounds, were identified by conventional static headspace gas chromatography mass spectrometry and another six monoterpene compounds were found and identified by the post-target method. Post-target analysis is a useful strategy in qualitative research of natural products.

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Section: European Journal Of Mass Spectrometrymentioning

confidence: 99%

Application of Gas Chromatography-Quadrupole-Time-of-Flight-Mass Spectrometry for Post-Target Analysis of Volatile Compounds in Fructus Amomi

Kang

Zhang

et al. 2013

Eur J Mass Spectrom (Chichester)

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“…For static HS‐GC, the conversion of water into a solid crystalline hydrate form using appropriate hygroscopic salts was a usual method to reduce the amount of water transferred to the column . This method was insufficient for removing large amounts of water vapor from high‐water‐content‐samples .…”

Section: Introductionmentioning

confidence: 99%

Determination of highly volatile compounds in fresh onion (Allium cepa L.) by room‐temperature enrichment headspace‐trap coupled to cryotrapping GC–MS

Liu

Guo

2018

Separation Science Plus

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Conventional headspace‐based analysis is not suitable for identifying volatile compounds in fresh onion (Allium cepa L.) because large amounts of water vapor could affect the determination of target compounds. A headspace‐trap was introduced to remove water vapor and keep the analytes in the trap tube. Additionally, the headspace‐trap method based on room‐temperature enrichment could prevent enzyme‐sensitive samples from denaturing to maintain the original flavor compositions of the samples. Moreover, the highly volatile compounds were poorly separated after headspace extraction. By using a cryotrapping device, these compounds were well separated. Therefore, a room‐temperature enrichment headspace‐trap cryotrapping gas chromatography with mass spectrometric method was established for the determination of volatile compounds in fresh onion. With this method, a total of 73 volatile compounds were identified by mass spectral search and retention index. Among them, 29 highly volatile compounds were successfully separated before the retention time of 5 min, and these compounds contributed significantly to the smell of onion. The volatile compounds were dominated by dipropyl disulfide (35.42%), 1,2‐dithiolane (15.82%), 1‐propanethiol (11.74%) and propanal (11.23%). The results indicated that the proposed method was an effective tool for analyzing volatile compounds in high‐water‐content fresh onion samples.

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“…The components eluting within the total ion chromatogram were extracted in AMDIS, matrix interference was then resolved, and overlapping components were removed. Then the compounds were positively identified using the National Institute of Standards and Technology (NIST) 05L Mass Spectra Database containing about 107,000 compounds, as well as comparison with the literatures [ 18 , 25 , 26 ]. The semiquantitative analysis of volatile compounds was performed by comparing their peak areas to that of the internal standard compound on the GC-MS total ion chromatogram.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Volatile Components between Raw and Vinegar Baked Radix Bupleuri by GC-MS Based Metabolic Fingerprinting Approach

Xing

Sun

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Radix Bupleuri (RB), also named Chaihu in Chinese, is a commonly used herbal drug in traditional Chinese medicine (TCM), and the processing of RB with vinegar to prepare vinegar-baked Radix Bupleuri (VBRB) has a long history in the clinic of TCM. In the present study, GC-MS coupled with multivariate data analysis was applied to compare the volatile components between crude and two vinegar processed RBs. After vinegar baking, the oil yields were decreased significantly, and the chemical compositions were also changed greatly. The chemical changes included the disappearance or appearance, as well as the content increase or decrease of some volatile compounds. The oil yields of two different VBRBs showed no significant difference but differed markedly in their chemical compositions, suggesting that the type of vinegar exerted great impacts on the vinegar-baking process. Thus, the effect of different vinegars on processing should be further investigated to ensure the therapeutic effect and safety of VBRB in clinic.

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Analysis of Volatile Compounds in Radix Bupleuri Injection by GC–MS–MS

Cited by 12 publications

References 42 publications

Application of Gas Chromatography-Quadrupole-Time-of-Flight-Mass Spectrometry for Post-Target Analysis of Volatile Compounds in Fructus Amomi

Application of Gas Chromatography-Quadrupole-Time-of-Flight-Mass Spectrometry for Post-Target Analysis of Volatile Compounds in Fructus Amomi

Determination of highly volatile compounds in fresh onion (Allium cepa L.) by room‐temperature enrichment headspace‐trap coupled to cryotrapping GC–MS

Comparison of Volatile Components between Raw and Vinegar Baked Radix Bupleuri by GC-MS Based Metabolic Fingerprinting Approach

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