Analysis of Vocal Fold Function in the Miniswine Model

Blakeslee, Don B.; Banks, R. E.; Eusterman, Vincent D.; Brooks, Danel

doi:10.3109/08941939509031607

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…Pigs are established models in human phoniatry [ 8 – 14 ]. Nonetheless, care has to be taken to respect the specific anatomy of the porcine glottis [ 15 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Histological Components of the Phoniatrical Body-Cover Model in Minipigs of Different Ages

et al. 2015

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Pigs are models in human phoniatry. However, features of maturation and ageing have not been considered with regard to the so-called body-cover model in this species. Therefore, the glottis of “young” (2–3 months; n = 6) and “old” (4–7 years; n = 6) minipigs was investigated. Their cranial (CraF) and caudal (CauF) vocal folds were histomorphometrically and stratigraphically analysed with emphasis on their amounts of collagen structures and elastic fibres. A dense subepithelial layer (SEL) was a distinct feature of CraF and CauF of both age groups; it was spread upon the underlying loose, flexible “cover” like a fibro-elastic membrane. The “cover” was characterised by the so-called superficial layer (SL), which was distinctly loose in the “young” minipigs, but had a much denser texture in the “old” minipigs. Here, the SL was dominated by elastic fibres in the CraF, but was of mixed qualities (collagenous and elastic) in the CauF. The structural requirements for the SL’s function as a loose “cover” were thus met only in the “young” animals. A clearly demarcated intermediate layer (IL)—characterised by high amounts of elastic fibres (as in humans)—was only found in the CraF of the “young” animals. In the “old” animals, it had lost its demarcation. In the depth of the CraF of the “old” animals, many thick collagen fibre bundles were detected in a location equivalent to that of the vocal muscle in the CauF. The development of their large diameters was interpreted as part of the maturation process, thereby supporting the hypothesis of their functional importance as a component of the “body.” In the CauF, the amounts of collagen structures increased throughout the entire lamina propria, resulting in a loss of demarcated stratigraphical subdivisions in the “old” minipigs. This situation resembled that described in the vocal fold of geriatric humans.

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“…Pigs are established models in human phoniatry [ 8 – 14 ]. Nonetheless, care has to be taken to respect the specific anatomy of the porcine glottis [ 15 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Histological Components of the Phoniatrical Body-Cover Model in Minipigs of Different Ages

et al. 2015

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“…To develop an effective treatment, it is necessary to understand the structural changes that occur with scarring. Histological studies using animal models have found dense and/or disorganized collagen deposition 9–11 and decreased and/or disorganized elastin. 9,12 In general, collagen accumulates in scar tissue and plays an important role in increasing tissue tensile strength.…”

Section: Introductionmentioning

confidence: 99%

Prevention of Vocal Fold Scarring by Topical Injection of Hepatocyte Growth Factor in a Rabbit Model

Hirano¹,

et al. 2004

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“…Studies have shown that increases in collagen -especially type 1 collagen -promote fibrosis, and that collagen content has direct impact on scar strength. 20 In the case of vocal fold fibrosis, dense collagen deposits have also been found in the injured lamina propria of animal model vocal folds [21][22][23] . However, recent research suggests that other components of the extracellular matrix such as hyaluronic acid, fibronectin, and decorin may also affect fibrous tissue.…”

Section: Literature Reviewmentioning

confidence: 99%

Injeção de corticosteróide em patologias vocais inflamatórias crônicas, revisão da literatura

Campagnolo

Tsuji

Sennes

et al. 2008

Rev. Bras. Otorrinolaringol.

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Os corticosteróides são potentes inibidores da inflamação e da cicatrização. Administração local de esteróides diretamente na laringe tem sido relatada em diversas patologias laríngeas. OBJETIVO: O objetivo desse estudo é realizar uma revisão da literatura sobre o uso de infiltração de corticosteróide em pregas vocais, em pacientes com patologias vocais benignas, inflamatórias e crônicas de laringe. METODOLOGIA: Realizou-se uma busca eletrônica na base de dados Medline, selecionando-se estudos clínicos que utilizavam corticosteróides em patologias benignas da laringe. RESULTADOS: Os corticosteróides são indicados nas seguintes situações: 1) doenças inflamatórias agudas, principalmente naquelas relacionadas a edema que comprometa a via aérea; 2) doenças auto-imunes com alterações laríngeas; 3) estenose laríngea; 4) em lesões benignas inflamatórias das pregas vocais, como nódulos, pólipos e edema de Reinke, para diminuir o processo inflamatório pré-cirúrgico ou na tentativa de se evitar uma intervenção cirúrgica; 5) em fonocirurgia, com o objetivo de reduzir a formação de cicatriz. Seu uso pode ser profilático, visando à prevenção da formação de cicatriz ou terapêutico em uma cicatriz já formada. CONCLUSÃO: Os corticosteróides podem ser considerados uma opção terapêutica importante no manejo de várias patologias, principalmente aquelas de origem inflamatória que causam alterações vocais.

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Analysis of Vocal Fold Function in the Miniswine Model

Cited by 14 publications

References 23 publications

The Histological Components of the Phoniatrical Body-Cover Model in Minipigs of Different Ages

The Histological Components of the Phoniatrical Body-Cover Model in Minipigs of Different Ages

Prevention of Vocal Fold Scarring by Topical Injection of Hepatocyte Growth Factor in a Rabbit Model

Injeção de corticosteróide em patologias vocais inflamatórias crônicas, revisão da literatura

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