Analysis of virus-specific B cell epitopes reveals extensive antigen processing prior to recognition
Alvaro Ras-Carmona,
Pedro A. Reche
Abstract:B cell epitopes must be solvent accessible for recognition by cognate B cells and antibodies. Here, we sought to study such premise for B cell epitopes targeted during infection in humans, available at the Immune Epitope Database. Most of these B cell epitopes were virus-specific linear B cell epitopes and so we focused on them, analyzing first the localization of the relevant antigens. Antigen localization could be unequivocally assigned to 26498 linear B cell epitopes. Of those, 18832 B cell epitopes belonge… Show more
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