Analysis of virion associated host proteins in vesicular stomatitis virus using a proteomics approach

Moerdyk-Schauwecker, Megan; Hwang, Sun-Il; Grdzelishvili, Valery Z.

doi:10.1186/1743-422x-6-166

Cited by 44 publications

(48 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Virus Production-Vesicular stomatitis virus (VSV) was prepared as described previously (35). In brief, ARPE-19 cells were inoculated with VSV, and virus containing media were collected at 24 h postinfection.…”

Section: Generation Of Soluble Tam Receptor Construct and Pngasefmentioning

confidence: 99%

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

Tsou

Nguyen²,

Calarese³

et al. 2014

Journal of Biological Chemistry

185

203

View full text Add to dashboard Cite

Background:The mechanisms by which ligands activate TAM receptors (TYRO3, AXL, and MER) are not well understood. Results:We created a series of TAM reporter cell lines and interrogated ligand-inducible TAM activation. Conclusion: TAMs are differentially activated by GAS6 and protein S and have distinct requirements for phosphatidylserine. Significance: Results reveal molecular mechanisms and rationale for non-overlapping functions of TAMs.

show abstract

Section: Generation Of Soluble Tam Receptor Construct and Pngasefmentioning

confidence: 99%

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

Tsou

Nguyen²,

Calarese³

et al. 2014

Journal of Biological Chemistry

185

203

View full text Add to dashboard Cite

show abstract

“…Importantly, phylogenetic analysis using the N gene sequence demonstrated that CTNCEC25 was more closely related to China indigenous RABV strains than other vaccine strains used in China using the complete genome sequence, the mature G protein amino acid sequence and the N gene sequence. As it has been shown that variations existed in virus-neutralizing antibody titer values when heterologous virus strains other than homologous virus strains were used as the challenge virus [18,19], it is therefore reasonable to assume that the best vaccine strain should be the one most closely related to the circulating strains within a target area. Further studies are undertaken to unravel the potential application of CTNCEC25 in rabies prevention and control in China.…”

Section: Resultsmentioning

confidence: 99%

Molecular Characteristics of the N Gene of the Chicken Embryo Cell- Adapted Rabies Virus Strain CTNCEC25

Zhu¹,

Li²,

Luo³

et al. 2015

J Vaccines Vaccin

View full text Add to dashboard Cite

Rabies virus is the prototypical species of neurotropic viruses and is the main causative agent of rabies, an ancient central nervous system disease that is almost invariably fatal. Recently, CTNCEC25, the China vaccine strain CTN-1 adapted to chicken embryo cells, was obtained and its complete genome was sequenced. Previous studies have demonstrated that CTNCEC25 possessed high immunogenicity and induced high levels of anti-rabies antibodies in animals. In the present study, the molecular characteristics and bioinformatic analysis of CTNCEC25 N gene was investigated. Sequence alignment showed that a single synonymous mutation was occurred in the CTNCEC25 N gene compared to the parent CTN-1 strain and all the important motifs and antigenic sites were conserved in CTNCEC25 N. The percentage homology of CTNCEC25 N gene with other rabies virus strains ranged from 99.9% to 84.8%. Phylogenetic analysis demonstrated that CTNCEC25 was closely related and clustered into the same group with most of those rabies virus street strains isolated in different regions in China. These results provide fundamental data to the characteristics of the CTNCEC25 N gene and pave the way for future application of CTNCEC25 for rabies control in China.

show abstract

“…In addition to IAV, AnxA1 is found associated with several other viruses [114][115][116][117][118][119][120][121][122]. Interestingly, no indications so far suggest that the viruses rely on its immune-modulating capacity to facilitate virus entry, although the AnxA1 receptor FPR2 is involved in IAV replication [123].…”

Section: Annexins and The Host/pathogen Interfacementioning

confidence: 99%

Annexins in Translational Research: HIDDEN Treasures to Be Found

Schloer¹,

Pajonczyk²,

Rescher³

2018

Preprint

View full text Add to dashboard Cite

The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca 2+ ) and phospholipid binding protein family which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca 2+ -controlled regulation of a broad range of membrane events. In this review, we identify and discuss several themes of annexin actions that hold a potential therapeutic value, namely the regulation of the immune response and the control of tissue homeostasis, and that repeatedly surface in the annexin activity profile. Our aim is to identify and discuss those annexin properties which might be exploited from a translational science and specifically clinical point of view.

show abstract

Analysis of virion associated host proteins in vesicular stomatitis virus using a proteomics approach

Cited by 44 publications

References 65 publications

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

Molecular Characteristics of the N Gene of the Chicken Embryo Cell- Adapted Rabies Virus Strain CTNCEC25

Annexins in Translational Research: HIDDEN Treasures to Be Found

Contact Info

Product

Resources

About