Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma

Taştekin, Ebru; Puyan, Fulya Öz; Akdere, Hakan; Yurut-Caloglu, Vuslat; Süt, Necdet; Can, Nuray; Özyilmaz, Filiz

doi:10.1590/s1677-5538.ibju.2015.0521

Cited by 19 publications

(28 citation statements)

References 28 publications

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“…In the multivariable model, male sex, stage ≥T3, tumor size, Fuhrman grade, and sarcomatoid differentiation were related only to the survival (p<0.05, S1 Table) similar to that reported in previous studies [4, 29, 30]. …”

Section: Discussionsupporting

confidence: 85%

The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry

Kim

Park

et al. 2017

PLoS ONE

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Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma (RCC). Methods Patients who underwent a nephrectomy during 1992–2015 and had a primary specimen of their kidney tumor were included. The nine tissue biomarkers were immunohistochemically stained on tissue microarrays of RCC, and the semi-quantitative H-score, including intensity score, was used to grade the sample. The Cox proportional hazards model was used to evaluate tissue markers significant for overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) after adjusting for significant clinicopathological parameters. Results Samples from 351 RCC patients were included. The mean age of the patients was 53.9 years; the rates of pathologic T1-2/≥T3 stage, Fuhrman 1+2/3+4 grade, recurrence, and death were 269/65(80.5/19.5%), 222/107 (67.5/32.5%), 6.6%, and 10.5%, respectively. Median OS, CSS, and RFS were 220.6, 220.6, and 147.1 months, respectively. The multivariable analysis showed that pathologic T stage and Fuhrman nuclear grade were significantly associated with OS and CSS. Pathologic T stage and tumor size were associated with RFS. After adjusting for these significant prognostic clinicopathological factors, Ki-67 was significantly associated with OS (hazard ratio [HR], 2.7), CSS (HR, 3.82), and RFS (HR, 4.85) and pS6 was associated with CSS (HR, 8.63) and RFS (HR, 8.51) in the multivariable model (p<0.05). Conclusion pS6 and Ki-67 are significant prognostic factors of RCC; however, BAP1, PBRM1, TGase 2, PD-L1, CA9, PTEN loss, and PSMA markers did not show this association.

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Section: Discussionsupporting

confidence: 85%

The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry

Kim

Park

et al. 2017

PLoS ONE

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“…In our study, most of the RCC cases were VEGF as grade-1 (42.0%) while 38% cases were VEGF grade-2 and 20% were VEGF grade-0 or with no staining which corroborate with the findings of Ebru T et al 19 who got only 4 cases which did not show staining while 27 cases (37.5%) showed strong VEGF staining.…”

Section: Figure 1 Hande Photomicrographs Of Different Subtypes Of Rccssupporting

confidence: 91%

“…This was similar to the studies done by Yildiz E et al, 16 Bürgesser M et al 18 and Osman WM et al 21 Expression of VEGF grades was seen to increase with the increase in stage of the tumours. This observation was found to be concordant with Ebru T et al, 19 Bürgesser M et al 18 and Osman WM et al 21 No significant difference was found in our study between different RCC types concerning cytoplasmic VEGF expression which is concordant with findings of Yildiz E et al 16 and Matušan-Ilijaš K et al 22 Furthermore, we noted that VEGF grade showed significant association with presence of necrosis and lymphovascular invasion which is similar to studies by Fujita N et al 23 and Veselaj F et al 24 In our study, we found the mean Ki-67 labelling index (mean ± s.d.) of the patients was 14.32 ± 3.88 with a range 5 -22 and the median was 15.0.…”

Section: Figure 1 Hande Photomicrographs Of Different Subtypes Of Rccssupporting

confidence: 91%

CORRELATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND Ki-67 EXPRESSION WITH HISTOLOGICAL GRADE AND STAGE OF RENAL CELL CARCINOMA

Chakraborty¹,

Sarkar²,

Bhattacharya³

et al. 2019

jemds

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BACKGROUND Renal cell carcinoma (RCC) is the most common malignant kidney tumour in adults. The vascular endothelial growth factor (VEGF) is thought to play a major role in tumour angiogenesis. Ki-67 has been shown to be of prognostic significance in RCCs. With the availability of more effective molecular targeted therapy for specific renal neoplasms, immunohistochemical (IHC) techniques play an important role in diagnosis and prognostication of RCCs. This study aims to evaluate the expression pattern of VEGF and Ki-67 in histologically diagnosed cases of RCC and correlate and compare VEGF and Ki-67 expression with grade and stage of RCC and also compare VEGF expression and Ki-67 index if any. MATERIALS AND METHODS This was a cross-sectional observational study. A total of 50 patients of RCC undergoing total and partial nephrectomy were included in this study. The expressions of Ki-67 and VEGF were studied by IHC. Statistical Analysis was performed with the help of Epi Info (TM) 7.2.2.2. p value of ≤0.05 was considered statistically significant. RESULTS Out of 50 tumours, 21 tumours were VEGF Grade 1, 19 tumours were VEGF Grade 2. 27 tumours had Ki67 labelling index≥15%. There was significant association of VEGF grades and Ki-67 labelling index with stage and histological grade. Ki-67 labelling index showed significantly increasing trend with the increase in VEGF grades of the tumours. CONCLUSION This study suggests that there are significant differences in VEGF expression and Ki-67 labelling index with tumour stage and grade and other prognostic parameters of RCC. These biomarkers can be considered as a prognostic parameters and critical evaluator of targeted chemotherapy in RCC. A wider evaluation involving large number of cases with proper follow up facility is needed to validate these findings.

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“…There was also selection bias in the selection and exclusion of patients, because we only selected the patients with complete information. In addition, many factors were not included, such as the statuses of VEGF, HIF-1α, HIF-2α, p53, and Ki-67 40,41 , which have been shown to in uence the prognosis of ccRCC. Because the included subjects had a higher survival rate and fewer subjects died during the follow-up period, the Validation curve only showed the portion with high survival rate.…”

Section: Limitationsmentioning

confidence: 99%

A practical nomogram for predicting cancer-specific survival in patients with clear-cell renal cell carcinoma

Wen

Wang

Bai

et al. 2020

Preprint

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Background: It has limitations in predicting patient cancer-specific survival to use of the traditional American Joint Committee on Cancer (AJCC) staging system alone. Objectives: We aimed to establish and evaluate a comprehensive prognostic nomogram and compare its prognostic value with the AJCC-7th staging system in adults diagnosed with ccRCC.Methods: We used the SEER database to identify 24477 cases of ccRCC between 2010 and 2015. In the development cohort, we used multivariate Cox proportional-hazards analyses to select significant variables, and used R software to establish a nomogram for predicting the 3-year and 5-year cancer-specific survival rates of ccRCC patients. In the development and validation cohorts, we compared our cancer-specific survival model with the AJCC-7th prognosis model to evaluate the performance of the nomogram by calculating the concordance index (C-index), Youden Index, area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI), and performing calibration plotting and decision curve analyses (DCAs). Results: Eleven identified independent prognostic factors were used to establish the nomogram. Age at diagnosis, being unmarried, higher grades, larger tumor size, higher AJCC-7th stage, lymph node metastases, bone metastases, liver metastases, lung metastases, radiotherapy, and no surgery were risk factors for the cancer-specific survival of ccRCC. The C-index, Youden Index, AUC, NRI, IDI, and calibration plots demonstrated the good performance of the nomogram compared to the AJCC-7th staging system. Moreover, the 3-year and 5-year DCA curves showed that the nomogram yielded net benefits that were greater than the traditional AJCC-7th staging system. Conclusion: This study is the first to indicate that married status is an important prognostic parameter in ccRCC. Our results also demonstrate that the developed nomogram can predict cancer-specific survival more accurately than the AJCC-7th staging system alone. The prognostic factors were easily obtained.

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Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma

Cited by 19 publications

References 28 publications

The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry

The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry

CORRELATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND Ki-67 EXPRESSION WITH HISTOLOGICAL GRADE AND STAGE OF RENAL CELL CARCINOMA

A practical nomogram for predicting cancer-specific survival in patients with clear-cell renal cell carcinoma

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