Analysis of variables and interactions among variables associated with a sustained virological response to pegylated interferon alfa-2a plus ribavirin in hepatitis C virus genotype 3-infected patients

Aziz, Hafsa; Raza, Abida; Waheed, Yasir; Gill, Uzma; Gill, Muzaffar Lateef

doi:10.1016/j.ijid.2012.03.012

Cited by 21 publications

(24 citation statements)

References 24 publications

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“…We did not confirm the correlation between pretreatment ALT level and sustained virological response observed by some investigators [6, 25, 27, 28]. …”

Section: Discussioncontrasting

confidence: 97%

Predictors of sustained virological response in patients with hepatitis C virus genotype 3 infection

Zarębska-Michaluk

Lebensztejn

Chrapek

et al. 2016

ceh

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Aim of the studyTo assess predictors of sustained virological response (SVR) in patients with chronic hepatitis C virus (HCV) genotype 3 treated with standard therapy.Material and methodsWe retrospectively investigated data of 116 consecutive treatment-naïve patients chronically infected with HCV genotype 3, treated with pegylated interferon alpha (PegIFNα) and ribavirin (RBV) for 24 weeks. HCV RNA at week 4 (rapid virological response – RVR) and week 12 (early virological response – EVR) were measured in 85 and 105 patients respectively. Liver biopsy data were available for 103 patients. The variables were compared between patients with an SVR and those without.ResultsOverall 70.7% of patients achieved an SVR. Pretreatment factors including younger age, mild liver fibrosis as well as normal values of gamma-glutamyl transferase (GGT) and platelet count were significantly associated with higher SVR rate in univariate analysis. In the multivariate analysis only baseline platelet count > 140 000/µl and normal GGT activity were correlated with higher SVR rate. At weeks 4 and 12 HCV RNA was undetectable in 34.1% and 84.8% of patients respectively. The SVR rate was significantly higher in patients with an RVR compared to those without (p = 0.002). Only 2 patients with a rapid and early virological response did not achieve an SVR; both had negative pretreatment prognostic factors.ConclusionsIn treatment-naïve patients with genotype 3 HCV infection, low baseline platelet count and elevated GGT activity were significantly associated with poor response to PegIFNα and RBV. Achieving a rapid and early virological response was associated with higher likelihood of an SVR.

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“…We did not confirm the correlation between pretreatment ALT level and sustained virological response observed by some investigators [6, 25, 27, 28]. …”

Section: Discussioncontrasting

confidence: 97%

Predictors of sustained virological response in patients with hepatitis C virus genotype 3 infection

Zarębska-Michaluk

Lebensztejn

Chrapek

et al. 2016

ceh

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“…In agreement with Puoti et al, 28 who reported rates of RVR and SVR in HCV genotype 3 patients of 64% and 82%, respectively, our study also showed the SVR rate achieved in RVR patients to be higher as compared to the rate achieved in patients who did not have RVR (88.3% vs. 63.6%, p < 0.001), showing that RVR is a strong predictor of SVR. 29 It also suggests that the week-4 virological response is a useful guide for treatment duration in HCV genotype 3 infection. Shortening the treatment period for chronic HCV infection is of major importance because this will reduce the costs for both patients and society.…”

Section: Discussionmentioning

confidence: 99%

Rapid virological response tailors the duration of treatment in hepatitis C virus genotype 3 patients treated with pegylated interferon alfa-2a and ribavirin in Pakistan

Gill

Aziz

Gill

2013

International Journal of Infectious Diseases

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“…The rapid virological response (RVR), defined as an undetectable hepatitis C viral load 4 weeks after the beginning of treatment, has been one of the factors most strongly associated with the achievement of SVR. [8][9][10] HIV-HCV coinfected patients have lower rates of HCV SVR compared with monoinfected patients (40% vs. 54-63%, respectively). Although the causes of lower response still remain unclear, coinfected patients have higher baseline viral loads and faster progression of the disease to liver fibrosis, as well as an increased risk of cirrhosis and hepatocellular carcinoma.…”

Section: ■■ Methodsmentioning

confidence: 99%

Antiviral Regimen Complexity Index as an Independent Predictor of Sustained Virologic Response in Patients with Chronic Hepatitis C

Galán

Cidoncha²,

Martín³

et al. 2013

JMCP

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BACkgRound: Hepatitis C virus (HCV) infection affects more than 170 million people worldwide, and one-third of them have human immunodeficiency virus (HIV) coinfection. Multiple studies have been conducted in order to identify the factors that may explain different responses to treatment among patients. However, the reasons why HIV-HCV coinfected patients have lower responses to treatment are not clear. In addition, no studies have evaluated the influence of the complexity of the therapeutic regimen for hepatitis C infection on clinical outcomes.

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Analysis of variables and interactions among variables associated with a sustained virological response to pegylated interferon alfa-2a plus ribavirin in hepatitis C virus genotype 3-infected patients

Abstract: RVR is an independent variable that is predictive of SVR. Moreover older patients (>40 years) who achieve an RVR are likely to have an SVR, while patients who do not achieve an RVR and who have a high pre-treatment viral load (>8 × 10(5) IU/ml) are unlikely to have an SVR.

Cited by 21 publications

References 24 publications

Predictors of sustained virological response in patients with hepatitis C virus genotype 3 infection

Predictors of sustained virological response in patients with hepatitis C virus genotype 3 infection

Rapid virological response tailors the duration of treatment in hepatitis C virus genotype 3 patients treated with pegylated interferon alfa-2a and ribavirin in Pakistan

Antiviral Regimen Complexity Index as an Independent Predictor of Sustained Virologic Response in Patients with Chronic Hepatitis C

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