Analysis of up-to-date studies investigating effects of physical rehabilitation on traditional and novel biochemical parameters in PAD patients with intermittent claudication: a review

Skórkowska-Telichowska, Katarzyna; Pilch, Urszula; Szuba, Andrzej

doi:10.5603/aa.2015.0013

Cited by 1 publication

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References 53 publications

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“…14 However, less attention has been paid to whether SET can also impact on the CV risk profile of these patients. 15 Interestingly, one small retrospective study has shown that SET significantly altered CV morbidity and mortality in 64 patients completing SET compared with those who did not. 16 The primary driver behind this observation remains unclear, but the impact of exercise on traditional CV risk factors, and therefore risk of future morbidity and mortality, has already been established in patients presenting with similar CV risk profiles.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Supervised Exercise Training on Traditional Cardiovascular Risk Factors in Patients With Intermittent Claudication: A Systematic Review and Meta-Analysis

Cornelis

Nassen

Buys

et al. 2019

European Journal of Vascular and Endovascular Surgery

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WHAT THIS PAPER ADDS This systematic review and meta-analysis shows for the first time that supervised exercise training in patients with intermittent claudication has the potential to reduce cardiovascular risk factors in addition to improving pain free and maximum walking distance. Moreover, this report highlights the lack of data on the effect of claudication limited exercise on cardiovascular risk factors. Therefore, this paper can encourage other exercise researchers to evaluate cardiovascular risk outcomes and therefore study the added value of exercise in secondary prevention of peripheral artery disease. Background: Patients with intermittent claudication (IC) are at increased risk of cardiovascular (CV) morbidity and mortality. Whereas extensive evidence supports the beneficial effects of supervised exercise training (SET) on walking capacity, little is known about the effect of SET on the CV risk profile of IC patients. Therefore, the aim was to evaluate the effects of SET on CV risk factors in IC patients by using metaanalysis techniques. Methods: A systematic search in the electronic databases MEDLINE, EMBASE, CINAHL, and CENTRAL was conducted from the earliest date available until October 2, 2018. Randomised and non-randomised controlled trials lasting ! four weeks and investigating the effect of SET on CV risk factors in IC patients were included. Traditional CV risk factors were studied as primary outcomes; pain free walking distance (PFWD) and maximum walking distance (MWD) were included as secondary outcomes. Data were pooled using random effects models with summary data reported as weighted means and 95% confidence interval (CIs). Results: Fifteen trials were included, involving 18 study groups (nine walking, four resistance, two aerobic training, and three combined groups), totalling 725 patients (mean age 66.3 years; mean ankle brachial index, 0.64). Exercise reduced systolic blood pressure (À5.8 mmHg; CI e9.89 to 1.67, p < .01) whereas all other CV risk factors (i.e., body weight, body mass index, diastolic blood pressure, and blood lipids) remained statistically unaltered. Exercise also improved PFWD (þ132 m; CI 70e194, p < .001) and MWD (þ183 m; CI 98e268, p < .001). Conclusion: This meta-analysis supports the beneficial effects of SET on walking capacity. Little evidence for an improvement of the CV risk profile was found following exercise in patients with IC. However, given the scarcity of data, high quality RCTs that include an assessment of CV risk factors are urgently required to determine the effect of exercise therapy in the secondary prevention of CV disease of IC patients.

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Section: Introductionmentioning

confidence: 99%

The Impact of Supervised Exercise Training on Traditional Cardiovascular Risk Factors in Patients With Intermittent Claudication: A Systematic Review and Meta-Analysis

Cornelis

Nassen

Buys

et al. 2019

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

Analysis of up-to-date studies investigating effects of physical rehabilitation on traditional and novel biochemical parameters in PAD patients with intermittent claudication: a review

Abstract: Peripheral arterial disease severity ranges from asymptomatic (Fontaine stage I) through intermittent claudication (Fontaine stage II) to critical ischaemia (stage III and IV). Supervised exercise training is the main therapy used

Cited by 1 publication

References 53 publications

The Impact of Supervised Exercise Training on Traditional Cardiovascular Risk Factors in Patients With Intermittent Claudication: A Systematic Review and Meta-Analysis

The Impact of Supervised Exercise Training on Traditional Cardiovascular Risk Factors in Patients With Intermittent Claudication: A Systematic Review and Meta-Analysis

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