Analysis of two T-cell receptor BV gene segment polymorphisms in caucasoid Brazilian patients with rheumatoid arthritis

Dresch, C; Xavier, Ricardo Machado; Brenol, João Carlos Tavares; Nardi, Nance Beyer

doi:10.1016/s0165-2478(03)00174-3

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…In previous studies, two TCR BV gene segments (TCR BV3S1 and TCR BV18) in RA were analyzed. The research found that neither allelic frequencies nor genotypic frequencies differ among RA and healthy individuals, suggesting that there was no direct association among the TCR BV allelic variants studied and the development of RA (Dresch et al, 2003). We analyzed the TCR BV gene mRNA expression in the experimental rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Triptolide on T‐Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen‐Induced Arthritis

Wang

Zeng

et al. 2012

The Anatomical Record

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Triptolide (TP) has been used in the treatment of rheumatoid arthritis (RA), but its mechanism of action is not understood. T-cell activation and associated release of cytokines appear to be major factors in the pathogenesis of RA. The overexpression of T-cell receptor (TCR) variable gene (V gene) fragments can cause the activation and infiltration of autoreactive T cells. This study examines the effects of TP on rats with collagen-induced arthritis (CIA). The levels of interleukin-10 (IL-10) in the serum were examined with ELISA. Compared to the CIA group, the levels of IL-10 were greater in the TP treatment group. Real-time quantitative polymerase chain reaction confirmed that the expression of TCR V beta (BV) 15 and TCR BV19 was increased in the CIA group, whereas in the TP treatment group, the expression was decreased. In this study, TP was found to enhance IL-10 levels and decrease the expression levels of TCR BV15 and TCR BV19. These changes might help explain the effectiveness of TP in the treatment of RA. Anat Rec,

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Section: Discussionmentioning

confidence: 99%

Effect of Triptolide on T‐Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen‐Induced Arthritis

Wang

Zeng

et al. 2012

The Anatomical Record

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show abstract

“…For instance, the presence of polymorphic stop codons in the TCRBV gene repertoire of certain inbred mouse strains [16] has been ascribed to a protective mechanism leading to the clonal deletion of autoimmune cells reactive to self [17] as well as to foreign [18] superantigens. However, the lack of association between TCRBV3 and TCRBV20 allelic variants and disease susceptibility observed in patients affected by rheumatoid arthritis argues against this hypothesis [19].…”

Section: Discussionmentioning

confidence: 99%