Analysis of two polymorphisms of the manganese superoxide dismutase gene (Ile-58Thr and Ala-9Val) in patients with recurrent depressive disorder

Gałecki, Piotr; Śmigielski, Janusz; Florkowski, Antoni; Bobińska, Kinga; Pietras, Tadeusz; Szemraj, Janusz

doi:10.1016/j.psychres.2009.06.016

Cited by 45 publications

(21 citation statements)

References 51 publications

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“…Polymorphisms of SOD2 have been reported to be associated with the development of neurodegenerative diseases, such as Alzheimer disease (51) and Parkinson disease (52,53), as well as psychiatric disorders, such as schizophrenia (54), depression (55), and bipolar disorder (56). Notably, neuroinflammation is closely linked to the onset and/or development of these CNS diseases (1)(2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia

Ishihara

Takemoto

Itoh

et al. 2015

Journal of Biological Chemistry

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Background:The redox state can affect the proinflammatory responses of microglia. Results: Superoxide dismutase 2 (SOD2) knockdown in activated microglia increased the production of reactive oxygen species (ROS) as well as inflammatory cytokines. Conclusion: SOD2 negatively regulates the inflammatory cytokine expression via ROS elimination. Significance: Our findings demonstrate a novel mechanism regulating microglial proinflammatory responses via oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia

Ishihara

Takemoto

Itoh

et al. 2015

Journal of Biological Chemistry

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“…Stefanescu and Ciobica showed that the antioxidant enzyme activity is decreased and the levels of lipid peroxidation is increased in major depression [22] . In addition, the polymorphisms of SOD (rs4880) [9] and GPX1 (rs1050450) [10] genes have also been implicated in major depression. Previous studies revealed a higher percentage of comorbidity with depression in MOH patients than in migraine patients [11,12] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, SOD (rs4880) [9] and glutathione peroxidase-1 (GPX1, rs1050450) [10] polymorphisms have also been implicated in major depression which is recognized as a risk factor for the development of MOH in migraine patients [11,12] . However, to the best of our knowledge, there have been no studies on the relationship between antioxidant enzyme gene polymorphisms and MOH.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Enzyme Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache

Ishii

Hirano

Katoh

2015

International Journal of Neurology Research

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“…Polymorphisms in SOD2 have been associated with the development of neurodegenerative diseases, such as Alzheimer’s [2] (A16V) and Parkinson’s disease [3] [4] [1] (A16V and I82T), as well as psychiatric disorders, such as schizophrenia [5], depression [6] and bipolar disorder [7]. Similarly, clinical trials showed improvement in symptoms in response to treatment with the glutathione precursor NAC in patients with schizophrenia and bipolar disorder [8] [9], suggesting that defects in the oxidative stress pathway may contribute to the pathogenesis of various diseases and symptoms.…”

Section: Introductionmentioning

confidence: 99%

Structural Modeling and In Silico Analysis of Human Superoxide Dismutase 2

Carvalho

Mesquita

2013

PLoS ONE

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Aging in the world population has increased every year. Superoxide dismutase 2 (Mn-SOD or SOD2) protects against oxidative stress, a main factor influencing cellular longevity. Polymorphisms in SOD2 have been associated with the development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, as well as psychiatric disorders, such as schizophrenia, depression and bipolar disorder. In this study, all of the described natural variants (S10I, A16V, E66V, G76R, I82T and R156W) of SOD2 were subjected to in silico analysis using eight different algorithms: SNPeffect, PolyPhen-2, PhD-SNP, PMUT, SIFT, SNAP, SNPs&GO and nsSNPAnalyzer. This analysis revealed disparate results for a few of the algorithms. The results showed that, from at least one algorithm, each amino acid substitution appears to harmfully affect the protein. Structural theoretical models were created for variants through comparative modelling performed using the MHOLline server (which includes MODELLER and PROCHECK) and ab initio modelling, using the I-Tasser server. The predicted models were evaluated using TM-align, and the results show that the models were constructed with high accuracy. The RMSD values of the modelled mutants indicated likely pathogenicity for all missense mutations. Structural phylogenetic analysis using ConSurf revealed that human SOD2 is highly conserved. As a result, a human-curated database was generated that enables biologists and clinicians to explore SOD2 nsSNPs, including predictions of their effects and visualisation of the alignment of both the wild-type and mutant structures. The database is freely available at http://bioinfogroup.com/database and will be regularly updated.

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Analysis of two polymorphisms of the manganese superoxide dismutase gene (Ile-58Thr and Ala-9Val) in patients with recurrent depressive disorder

Cited by 45 publications

References 51 publications

Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia

Dual Role of Superoxide Dismutase 2 Induced in Activated Microglia

Antioxidant Enzyme Gene Polymorphisms in Japanese Migraine Patients with Medication Overuse Headache

Structural Modeling and In Silico Analysis of Human Superoxide Dismutase 2

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