Analysis of Treg Cell Population Alterations in the Peripheral Blood of Patients Treated Surgically for Ovarian Cancer - A Preliminary Report

Wicherek, Lukasz; Jóźwicki, Wojciech; Windorbska, Wiesława; Roszkowski, Krzysztof; Lukaszewska, Ewelina; Wiśniewski, Michał; Brożyna, Anna A.; Basta, Paweł; Skręt-Magierło, Joanna; Koper, Krzysztof; Rokitaⴕ, Wojciech; Dutsch-Wicherek, Magdalena

doi:10.1111/j.1600-0897.2011.01024.x

Cited by 20 publications

(19 citation statements)

References 31 publications

(37 reference statements)

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“…Statistically significant decreases of the percentage of Foxp3+CD4+CD25+ lymphocytes within the population of CD4+CD25+ lymphocytes and within the population of CD4+ T lymphocytes were observed following the surgical treatment. A similar observation was noted in ovarian cancer, where the percentages of FOXP3+ cells in the subpopulation of CD4+ T lymphocytes found in the peripheral blood of the patients before the surgical procedure were statistically significantly higher than those observed in the peripheral blood of the same patients after the surgical procedure [27]. The suppressive microenvironment in endometrial cancer is thus created by the recruitment of Treg cells into the tumour and its stroma and leads to an increase of the percentage of Treg cell population in the blood serum observed in various cancer patients [7,8].…”

Section: Discussionsupporting

confidence: 58%

“…The malignant neoplasm destroys, therefore, the host immune response, and the surgical treatment aims to remove the tumour mass radically and to restore the immune response. It was demonstrated that when the degree of surgery radicalism increases the possibility of restoring the immune function also increases [25][26][27]. There is no efficient method for the evaluation of surgical treatment radicalism.…”

Section: Introductionmentioning

confidence: 99%

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The analysis of the level of Treg lymphocytes in the blood of patients with endometrial cancer before and after the surgery — preliminary study

Biedka

Kuźba-Kryszak²,

Wicherek

et al. 2018

Medical Research Journal

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The analysis of the level of Treg lymphocytes in the blood of patients with endometrial cancer before and after the surgery -preliminary study ABSTRACT Introduction. The progression of cancer is a complex process involving host-tumour interactions taking place in cancer and in the cancer microenvironment. The tumour remodels the microenvironment into the suppressive profile by various mechanisms. One of the most important elements of this mechanism is the inducing of the infiltration of Treg lymphocytes into cancer and its microenvironment. The aim of the present study was to evaluate the alterations of the Treg cell population in the peripheral blood of patients before and after the surgical treatment for endometrial cancer.Material and methods. For the present study 24 patients with endometrial cancer were recruited. All the patients were treated surgically. The peripheral blood samples were collected from the endometrial cancer patients before operation and three days after the surgical procedure and evaluated using flow cytometry method.Results. CD25+ CD4+ FOXP3+ T cells were found in all the examined peripheral blood samples derived from the endometrial cancer patients in the days before and following applied surgery. We observed differences before and after the applied surgical procedure in patients treated for uterine cancer. The highest number of Treg cells in the peripheral blood was demonstrated before the surgical procedure; it diminished statistically significantly following the surgery.Conclusions. The decrease of the percentage of Treg cells in blood sera in patients following radical surgical treatment might be useful in measuring the radicalism of the treatment. The monitoring of the level of selective immune system suppression related to Treg cell blood serum levels during cancer therapy might support a decision to supplement the standard therapy with immunotherapy or to increase the degree of radicalism of the applied therapy.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

The analysis of the level of Treg lymphocytes in the blood of patients with endometrial cancer before and after the surgery — preliminary study

Biedka

Kuźba-Kryszak²,

Wicherek

et al. 2018

Medical Research Journal

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“…Patients and experimental models with cancer showed that Treg cells down-regulated the activity of effector function against tumors, resulting in T-cell dysfunction in cancerbearing hosts (Weiss et al, 2012;Sakuishi et al, 2013). An increased population of Treg cells was reported in patients with ovarian cancer (Wicherek et al, 2011), lung cancer (Erfani et al, 2012), and breast cancer (Decker et al, 2012). However, there are no previous reports describing Treg cells in gastric cancer.…”

Section: Introductionmentioning

confidence: 80%

Effects of Gastric Cancer Cells on the Differentiation of Treg Cells

Yang²,

Tang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The aim of this study was evaluated the prevalence of Treg cells in peripheral blood in patients with gastric cancer, and investigate the effect of gastric cancer cells on their differentiation. ELISA was employed to assess the concentrations of TGF-β and IL-10 in gastric cancer patients' serum. Then, mouse gastric cancer cells were co-cultured with T lymphocytes or T lymphocytes + anti-TGF-β. Flow cytometric analysis and RT-PCR were then performed to detect Treg cells and TGF-β and IL-10 expression in gastric cancer cells. Our data showed that the expression of TGF-β and IL-10 in the patients with gastric cancer was increased compared to the case with healthy donors. The population of Treg cells and the expression levels of TGF-β and IL-10 in the co-culture group were much higher than in the control group (18.6% vs 9.5%) (P<0.05). Moreover, the population of Treg cells and the expression levels of TGF-β and IL-10 in the co-culture systerm were clearly decreased after addition of anti-TGF-β (7.7% vs 19.6%) (P<0.01). In conclusion, gastric cancer cells may induce Treg cell differentiation through TGF-β, and further promote immunosuppression.

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“…Elevated Treg cell percentage have been already reported in breast, colorectal and ovarian cancers, as well as brain tumors, hepatocellular carcinoma (HCC) and multiple myeloma; condition which has been indicated to be associated with poor disease outcome in several studies [25][26][27][28][29][30][31]. It has been frequently suggested that the increase in Treg cell percentage may provide an immunetolerance toward cancer antigens [32,33].…”

Section: Discussionmentioning

confidence: 99%

Immune regulatory cells and IL17-producing lymphocytes in patients with benign and malignant salivary gland tumors

et al. 2015

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Analysis of Treg Cell Population Alterations in the Peripheral Blood of Patients Treated Surgically for Ovarian Cancer - A Preliminary Report

Cited by 20 publications

References 31 publications

The analysis of the level of Treg lymphocytes in the blood of patients with endometrial cancer before and after the surgery — preliminary study

The analysis of the level of Treg lymphocytes in the blood of patients with endometrial cancer before and after the surgery — preliminary study

Effects of Gastric Cancer Cells on the Differentiation of Treg Cells

Immune regulatory cells and IL17-producing lymphocytes in patients with benign and malignant salivary gland tumors

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