Analysis of total arsenic in urine and blood by high speed anodic stripping voltammetry

Davis, P. H.; Berlandi, Francis J.; Dulude, G.R.; Griffin, R.M.E.; Matson, Wayne R.; Zink, Eric W

doi:10.1080/0002889778507793

Cited by 8 publications

(1 citation statement)

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“…Blood vessels were unremarkable. The toxicological determinations of arsenic were performed on fresh samples of various tissues obtained at autopsy, using a specific and ultrasensitive electrochemical method adapted from Davis et al 4 Briefly, after acidic mineralization of fresh tissues and reduction to Ast3 by sodium sulfite and hydrazine, the arsenic content was determined by anodic stripping voltametry using a gold-graphite electrode (detection limit: 3ng/g of 642 Melarsoprol-Induced Neuropathy fresh tissue). Very high concentrations of arsenic were found in the spinal cord and renal tissue ( Table 3).…”

Section: Postmortem Datamentioning

confidence: 99%

Organic arsenic‐induced Guillain‐Barré‐like syndrome due to melarsoprol: A clinical, electrophysiological, and pathological study

et al. 1990

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A young woman suffering from sleeping sickness was treated with melarsoprol. Thirty-eight days after the first administration of this organo-arsenic compound, myalgias, distal paresthesias and rapidly progressive weakness developed in all four limbs. Electrophysiological studies were misleading for Guillain-Barré syndrome. Neuropathological data included massive distal wallerian degeneration in peripheral nerves and abnormalities in dorsal ganglia and spinal cord where vacuolation of anterior horn cells and axonal neurofilamentous masses were observed. Very high concentrations of arsenic were found in the spinal cord, contrasting with undetectable levels in peripheral nerves. Our findings are consistent with an arsenic neuronopathy manifested by initial proximal demyelination and delayed distal axonal damage. Renal and hepatic dysfunctions, which were implicated in the toxic arsenic accumulation, should be systematically detected before administration of melarsoprol. The diagnosis of Guillain-Barré syndrome must be considered with caution in patients treated with this compound.

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Section: Postmortem Datamentioning

confidence: 99%

Organic arsenic‐induced Guillain‐Barré‐like syndrome due to melarsoprol: A clinical, electrophysiological, and pathological study

et al. 1990

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Electroanalysis and Biosensors in Clinical Chemistry

Killard

Sequeira

Diamond

et al. 2000

Encyclopedia of Analytical Chemistry

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Electroanalysis involves the measurement or determination of a chemical or biochemical species, using a wide range of electrochemical methods. The species being measured can either bring about a direct electrochemical response that can be detected and measured, or can be induced to bring about such a response, resulting in a process that can be detected electrochemically. In both cases an interface is required between the chemical or biochemical species being measured, and the electrochemical system performing the measurement. This interface is referred to as an “electrode”. It is the transfer of electrons or ions between the electrode and the environment being sampled which is of concern in electroanalysis. The application of electrochemistry in clinical analysis is concerned with the measurement of chemical and biochemical species present in biological fluids (primarily blood but also urine and other body fluids and tissues). It is applied in several areas of critical care where its rapidity, sensitivity, precision, and accuracy at biologically relevant concentrations make it an ideal choice over other, typically slower, biochemical techniques. Indeed, it is the speed of electrochemical analysis that principally differentiates it from other methods. It is not universally applicable to clinical chemistry, however, and has only been applied in situations where such analyses are relevant. This has principally been in the analysis of blood gases and pH and blood electrolytes. Electrochemical methods are, however, gradually being extended to the analysis of small biochemical components such as sugars, amino acids and other metabolites, with the advent of enzyme‐based “biosensors”. There is also little doubt that the application of electrochemistry in clinical analysis will be further exploited by the use of such biosensor devices based on other forms of biorecognition, such as antibodies, cell ligands, membranes, tissues and whole cells. These biosensor devices are also amenable to other forms of detection such as acoustic wave and optical measurements. Together, these techniques offer a wide range of advantages over traditional analytical methodologies, and will undoubtedly have a rapidly increasing impact on many types of clinical analysis. This article focuses on the use of electrochemical techniques and electrochemical biosensors and their application in clinical chemistry.

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Bestimmung von As (III) in Körperflüssigkeiten eines Vergiftungsopfers mit der Differentialpuls-Anodic-Stripping-Voltammetrie

Daldrup¹,

Winkelmann²,

Osberghaus³

et al. 1986

Medizin Und Recht

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Analysis of total arsenic in urine and blood by high speed anodic stripping voltammetry

Cited by 8 publications

References 0 publications

Organic arsenic‐induced Guillain‐Barré‐like syndrome due to melarsoprol: A clinical, electrophysiological, and pathological study

Organic arsenic‐induced Guillain‐Barré‐like syndrome due to melarsoprol: A clinical, electrophysiological, and pathological study

Electroanalysis and Biosensors in Clinical Chemistry

Bestimmung von As (III) in Körperflüssigkeiten eines Vergiftungsopfers mit der Differentialpuls-Anodic-Stripping-Voltammetrie

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