Analysis of Three Outbreaks Due toKlebsiellaSpecies in a Neonatal Intensive Care Unit

Abstract

Klebsiella outbreaks mainly affected premature neonates with intravenous catheters, mechanical ventilation, or both. The high mortality rate (76.7%) was notable. Resistance to multiple antibiotics, but mainly to broad-spectrum beta-lactam antibiotics, was observed, particularly in K. pneumoniae isolates. Molecular typing indicated that the three outbreaks were not related to one other.

Outbreak of Extended Spectrum Beta Lactamase Producing Klebsiella Species Causing Neonatal Sepsis at Patan Hospital in Nepal

“…ESBL Klebsiella has also been liked to artificial nails. 19 Melek Ayan et al 20 reported Klebsiella outbreaks in premature neonates with intravenous catheters, mechanical ventilation or both, and high mortality rate (76.7%) was noted. In this study, more than half of the patients had low birth weight, were premature, or underwent mechanical ventilation.…”

Estudo etiológico da diarréia em crianças hospitalizadas no Instituto Materno Infantil Prof. Fernando Figueira, IMIP, em Recife, Pernambuco

“…30 Além do potencial enteropatogênico, as 20 Entre essas, as Enterobacteriaceae ESBL + ocupam lugar de destaque em infecções da faixa pediátrica. [21][22][23][24][25] As ESBLs são um conjunto de enzimas capazes de hidrolisar penicilinas, cefalosporinas de largo espectro e monobactâmicos. 22 São codificadas em genes localizados no cromossomo ou nos plasmí-dios.…”

Two outbreaks of ESBL‐producing Klebsiella pneumoniae in a neonatal intensive care unit

“…Klebsiella pneumoniae is the Klebsiella species most frequently isolated from nosocomial infections . An increase in K. pneumoniae strains that produce extended spectrum beta‐lactamase (ESBL) due to extensive use of cephalosporins has been reported in recent years throughout the world …”

“…The pathogen ESBL‐producing K. pneumoniae is frequently encountered in outbreaks occurring especially in neonatal intensive care units (NICU) . Given that K. pneumoniae spreads through direct contact and has a high rate of colonization, the bacteria easily cause outbreaks.…”