Analysis of therapeutic and commonly abused drugs in serum and urine by gas—liquid chromatography using a photoionization detector

Jaramillo, Luis Fernando; Driscoll, John S.

doi:10.1016/s0021-9673(00)95284-1

Cited by 13 publications

(1 citation statement)

References 8 publications

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“…This behavior indicates that the photovoltaic detector is neither a concentration-sensitive device (signal independent of flow rate) nor a mass-sensitive device (signal increases linearly with flow rate) . This differs from the concentration sensitivity exhibited by the gas-phase photoionization detector. − This unexpected behavior is believed to arise from the high linear velocity in combination with the flow cell geometry (see Figure ). The photopotential arises from solute photoionization that occurs at or near the electrode surface during the laser pulse .…”

Section: Resultsmentioning

confidence: 96%

A Photovoltaic Detection System for Flow Injection and Liquid Chromatography

McGuffin

Judge

1999

Anal. Chem.

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A photoionization system has been developed for flow injection and liquid chromatographic applications that employs photovoltaic rather than traditional photoconductive detection. This detection system utilizes an excimer laser at 248 nm (5.0 eV) to achieve one-photon excitation in alcoholic, aqueous, and ionic solutions. The photovoltaic response is reported for a variety of solutes including aliphatic and aromatic amines, aldehydes, ketones, carboxylic acids, and halogenated compounds. The photovoltaic method is characterized with respect to solute concentration and flow rate. The detection limit is 5 × 10(-)(6) M (2.3 ng) for aniline in methanol with a linear dynamic range greater than 2 orders of magnitude, which compares favorably to UV-visible absorbance detection. Photovoltaic detection is demonstrated for a series of substituted anilines and aldehydes separated by reversed-phase liquid chromatography.

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