Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer

Friedrich, Michael; Rafi, Leyla; Mitschele, Tanja; Tilgen, Wolfgang; Schmidt, Werner; Reichrath, Jörg

doi:10.1007/978-3-642-55580-0_17

Cited by 129 publications

(101 citation statements)

References 8 publications

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“…Therefore, the inverse associations in our study might be attenuated among (Holick, 2003;Reichrath, 2007). In addition, Friedrich et al (2002Friedrich et al ( , 2003 indicated that messenger RNA and protein Calcium, vitamin D and cervical neoplasia risk S Hosono et al Calcium, vitamin D and cervical neoplasia risk S Hosono et al (Heaney, 2008). Although we did not examine serum vitamin D status, this mechanism could explain our results.…”

Section: Discussionmentioning

confidence: 56%

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

et al. 2010

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Background/Objectives: To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study. Subjects/Methods: We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models. Results: The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend ¼ 0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend ¼ 0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend ¼ 0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend ¼ 0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P ¼ 0.819; and CIN3: interaction P ¼ 0.101). Conclusion: We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.

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Section: Discussionmentioning

confidence: 56%

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

et al. 2010

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“…With the discovery that 25-hydroxy vitamin D 3 1α-hydroxylase (CYP27B1) is expressed in multiple vitamin D target tissues including pancreas, colon, breast and prostate [12][13][14][15], it is possible that 25(OH)D 3 , the major vitamin D metabolite present at much higher concentration in serum in comparison to that of 1,25(OH) 2 D 3 [16], may serve as a natural chemoprotective vitamin D in the body. 25(OH) D 3 can belocally converted to the active 1,25(OH) 2 , which is highly expressed in renal proximal tubules.…”

Section: Introductionmentioning

confidence: 99%

“…CYP27B1 was initially proved to be the 1α-hydroxylase found in proximal renal tubules that carries out the 1α-hydroxylation of 25(OH)D 3 and is the enzyme that is defective in vitamin D dependent rickets (VDDR) type 1 [18]. Recently 1α-hydroxylase has been shown to be expressed in various extrarenal sites in the body including mammary gland [12][13][14][15]. However, very limited information on CYP27B1 expression and regulation is available for mammary gland.…”

Section: Introductionmentioning

confidence: 99%

“…The CYP27B1 protein was expressed at comparable levels in mammary glands from WT and VDR knockout mice during pregnancy and lactation. Friedrich et al showed upregulated CYP27B1 mRNA in breast carcinomas as compared to normal tissue [14]. Since CYP27B1 is locally expressed in breast epithelial cells, 25(OH)D 3 , a natural non-toxic vitamin D metabolite which is present at high concentration in serum, could be developed as an ideal, natural cancer chemoprenventive agent.…”

Section: Introductionmentioning

confidence: 99%

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25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture

Xiang

Hawthorne

Vaishnav

et al. 2008

Breast Cancer Res Treat

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Despite the role of vitamin D 3 endocrine system in prevention of mammary gland transformation in animal models, use of 1,25(OH) 2 D 3 in clinical settings is precluded due to its toxicity in vivo. Therefore much effort has been placed in developing relatively non-toxic vitamin D analogs. Recently, with the discovery of the expression of 25-hydroxy vitamin D 3 1α-hydroxylase (CYP27B1) in multiple extrarenal organs, the functional role of prohormone, 25-hydroxyvitamin D 3 [25(OH) D 3 ], has been redefined. Since 25(OH)D 3 does not cause hypercalcemia and maintains relative high concentration in serum, it is possible that the prohormone can be converted to active hormone in mammary epithelial cells to provide chemopreventive effects. In the present study, we evaluated its functional significance using mouse mammary organ culture (MMOC) system. We first showed that 25(OH)D 3 1α-hydroxylase is extensively expressed in mammary ductal epithelial cells at both protein and mRNA levels, which is a prerequisite for 25(OH)D 3 to function in an autocrine/paracrine manner. However, we also observed that clotrimazol (1α-hydroxylase inhibitor) enhanced 25(OH) D 3 -induced CYP24 expression in breast cancer cells. In mammary glands derived from 1α-hydroxylase knockout mice, 25(OH)D 3 treatment in organ culture significantly induced CYP24 expression, indicating a potential direct effect of 25(OH)D 3 . In MMOC, 100-250 nM 25(OH)D 3 suppressed both ovarian hormone-dependent and -independent mammary precancerous lesions (induced by DMBA) by more than 50%, while the active hormone 1,25(OH) 2 D 3 (positive control) at 100 nM suppressed alveolar lesions by more than 80%. The inactive vitamin D 3 (negative control) at 100 nM suppressed alveolar lesions by only 20% (P > 0.05). We found that 25(OH)D 3 inhibits DMBA-induced mammary alveolar lesions (MAL) in a stage-specific manner: 25(OH)D 3 mainly inhibits the promotion stage of lesion formation. We conclude that 25(OH)D 3 could serve as a nontoxic natural chemopreventive agent for further development for breast cancer prevention.

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“…We observed a significant inverse association between breast cancer risk and plasma 25(OH)D concentrations. Compared with the lowest category (<30 nmol/L), the ORs (95% CI) for the upper categories [18][19][20] Few studies have assessed the relationship between serum or plasma 25(OH)D and breast cancer risk. [21][22][23][24][25] Of 2 small hospitalbased case-control studies in predominantly postmenopausal women, one study found a significantly inverse association 23 whereas the other study revealed no association between plasma 25(OH)D and breast cancer risk.…”

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confidence: 99%

Plasma 25‐hydroxyvitamin D and premenopausal breast cancer risk in a German case‐control study

Abbas

Chang‐Claude

Linseisen

2008

Intl Journal of Cancer

110

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Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopausal and postmenopausal breast cancer have been discussed, this is the first study to investigate the association of plasma 25-hydroxyvitamin D [25(OH)D], as indicator of the overall vitamin D status, with breast cancer risk with restriction to premenopausal women only. We used data of a population-based case-control study comprising 289 cases and 595 matched controls. Information on sociodemographic and breast cancer risk factors was collected by questionnaire and plasma 25(OH)D was measured by enzyme immunoassay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. We observed a significant inverse association between breast cancer risk and plasma 25(OH)D concentrations. Compared with the lowest category (<30 nmol/L), the ORs (95% CI) for the upper categories [18][19][20] Few studies have assessed the relationship between serum or plasma 25(OH)D and breast cancer risk. [21][22][23][24][25] Of 2 small hospitalbased case-control studies in predominantly postmenopausal women, one study found a significantly inverse association 23 whereas the other study revealed no association between plasma 25(OH)D and breast cancer risk. 25 To date, 2 studies assessed the association of vitamin D metabolites with breast cancer risk with restriction to postmenopausal women only. 21,22 A study nested in the prostate, lung, colorectal and ovarian cancer screening trial reported no association between both higher plasma 25(OH)D and 1,25(OH) 2 D concentration and breast cancer risk. 22 However, a strong statistically significant inverse association between postmenopausal breast cancer risk and serum 25(OH)D was found in a large case-control study. 21 A case-control study nested in the Nurses' Health Study (NHS) is the only study that so far reported results stratified by menopausal status. 24 The authors reported a nonsignificant decrease in breast cancer risk with both higher plasma 25(OH)D and 1,25(OH) 2 D concentration for overall breast cancer risk. Stratification by menopausal status suggested an inverse association for postmenopausal women only, however power was low for their analysis in premenopausal women and risk estimates were not presented. As reviewed recently, prospective studies on dietary intake of vitamin D suggest a more pronounced effect for premenopausal breast cancer risk. 26 Furthermore, we recently reported a significant inverse association of dietary vitamin D with premenopausal breast cancer risk in the present study population. 13 To our knowledge, no study so far assessed the association of plasma 25(OH)D with restriction to premenopausal breast cancer only. Following our previous report on the association between postmenopausal breast canc...

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Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer

Cited by 129 publications

References 8 publications

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture

Plasma 25‐hydroxyvitamin D and premenopausal breast cancer risk in a German case‐control study

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