Analysis of the unsaponifiable fraction of lipids belonging to various milk-types by using comprehensive two-dimensional gas chromatography with dual mass spectrometry/flame ionization detection and with the support of high resolution time-of-flight mass spectrometry for structural elucidation

Analysis of human plasma lipids by using comprehensive two‐dimensional gas chromatography with dual detection and with the support of high‐resolution time‐of‐flight mass spectrometry for structural elucidation

“…Five chemical classes (not considering the FAs) are nicely spread out on the 2D plane, with each one occupying a well‐defined zone: hydrocarbons (linear alkanes; squalene); TMS‐derivatized fatty alcohols; TMS‐derivatized glycerol ethers or monoalkylglycerols; TMS‐derivatized tocopherols; TMS‐derivatized sterols, accompanied by dehydration and oxidation products. As observed in the previous investigation , TMS‐derivatized FAs are also present, and although they could have been removed by an additional purification step (i.e. column chromatography), they were of no interference.…”

“…In a recent research, GC × GC with dual quadrupole (quad) MS/FID detection was used for the analysis of the entire unsaponifiable fraction (no TLC prefractionation was performed) of different milks ; 1D GC, combined with high‐resolution (HR) TOF‐MS, was exploited to support analyte identification (through accurate mass spectra).…”

Advanced Mass Spectrometry

“…There are also a number of applications to lipidomics [22], glycomics, metabolomics, and proteomics [60]. Table 2 summarizes the most important applications reported in the last 5 years.…”

“…The appearance of modern HRMS instruments such as TOF and Orbitrap has changed the situation. The use of HRMS in many fields of food safety and quality, including metabolite identification and structure elucidation, food contaminants, or food control, is notably increasing [22][23][24][25].…”

“…Effect of thermal processing [66] LC-TOF Analysis of pesticides in fruits and vegetables [67] GC-TOF Quantitative analysis of acetaldehyde in foods consumed [68] LC-TOF Screening natural antioxidants in peanut shell [69] UHPLC-TOF Hexabromocyclododecane diastereomers [70] Type Application References UHPLC-TOF 19 antibiotics in dairy products [71] MALDI-TOF Microscale strategy to detect spermine and spermidine in food [72] LC-TOF Determination of phthalates in edible salts from food markets in Korea [73] LC-QqTOF Simultaneous determination five major antioxidant compounds [74] MALDI-TOF Monitoring of she-donkey's milk contamination or adulteration [75] MALDI-TOF Quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators [76] LC-QqTOF Quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators [45] UHPLC-TOF Analysis of illicit dietary supplements sold in the Italian market: Identification of a sildenafil thioderivative as adulterant [46] LC-TOF Simultaneous investigation of sesquiterpenes, pyrrolizidine alkaloids, and N-oxides in butterbur (Petasites hybridus) [77] UHPLC-QqTOF Determination of 141 pesticides in tea [78] UHPLC-QqTOF Determination of tadalafil and N-desmethylsibutramine in health and dietary supplements [79] LC-QqTOF Seven fluorescent whitening agents in food contact paper package materials [80] Lipidomics GC × GC-TOF Unsaponifiable fraction of lipids belonging to various types of milk [22] UHPLC-QqTOF Rapid and highly accurate detection of steryl glycoside [81] MALDI-TOF Rapid lipid profiling of bacteria [82] MALDI-TOF Detection of glycated phospholipids in heattreated food samples [83] …”