Analysis of the Toxicity of a Cu2O Nanocomposite Encapsulated in a Polymer Matrix of Arabinogalactan

Титов, Е. А.; Соседова, Л. М.; Kapustina, E. A.; Yakimova, N. L.; Новиков, М. А.; Lisetskaya, L. G.; Lizarev, A. V.

doi:10.1134/s2635167621040145

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…We recently showed that exposure to gadolinium nanoparticles encapsulated in a polymer matrix of AG leads to an increase in the number of degeneratively altered neurons and neuronophagy in the sensorimotor cortex in rats [23]. In addition, we established the selective cytotoxicity of copper oxide nanoparticles on the AG matrix, causing a decrease in astroglial cells, which can also lead to disruption of the normal homeostasis of the nervous tissue [24]. It is believed that the biological effects of metal nanoparticles can be mediated either by the direct action of nanoscale structures entering the tissues as such or by the influence of ions that can be separated from the surface of the introduced nanostructures [25].…”

Section: Discussionmentioning

confidence: 99%

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Новиков

Титов

Соседова

et al. 2021

IJMS

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The aim of our investigation was to make a comparative assessment of the biological effects of silver nanoparticles encapsulated in a natural and synthetic polymer matrix. We carried out a comparative assessment of the biological effect of silver nanocomposites on natural (arabinogalactan) and synthetic (poly-1-vinyl-1,2,4-triazole) matrices. We used 144 three-month-old white outbred male rats, which were divided into six groups. Substances were administered orally for 9 days at a dose 500 μg/kg. Twelve rats from each group were withdrawn from the experiment immediately after nine days of exposure (early period), and the remaining 12 rats were withdrawn from the experiment 6 months after the end of the nine-day exposure (long-term period). We investigated the parietal–temporal area of the cerebral cortex using histological (morphological assessments of nervous tissue), electron microscopic (calculation of mitochondrial areas and assessment of the quality of the cell nucleus), and immunohistochemical methods (study of the expression of proteins regulating apoptosis bcl-2 and caspase 3). We found that the effect of the nanocomposite on the arabinogalactan matrix causes a disturbance in the nervous tissue structure, an increase in the area of mitochondria, a disturbance of the structure of nerve cells, and activation of the process of apoptosis.

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Section: Discussionmentioning

confidence: 99%

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Новиков

Титов

Соседова

et al. 2021

IJMS

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“…The choice of dose is due to previous studies of the toxic properties of nanocomposites of other metals (Ag, Bi, Fe, etc.) [ 28 , 29 , 30 , 31 , 32 , 33 ], indicating the development of clear and persistent signs of pathology with the introduction of this dose. Control animals ( n = 10) received 1 mL of distilled water in the same mode.…”

Section: Methodsmentioning

confidence: 99%

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

et al. 2022

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The acute and subacute toxicity of a newly synthesized silver selenide nanoparticles encapsulated in a natural polymeric matrix of arabinogalactan study has been studied. The nanocomposite is a promising material for the design of diagnostic and therapeutic drugs. It can also be used for the preparation of fluorescent labels and in thermal oncotherapy. The employment of binary nanocomposites enables one to unveil the potential hidden in metals which constitute these composites. The study of acute toxicity, carried out by the oral administration of nanocomposites at a dose of 2000 mg/kg, has shown that the compound belongs to low-toxic substances of the 5th hazard class. With the subacute oral administration of nanocomposites at a dose of 500 μg/kg, slight changes are observed in the brain tissue and liver of experimental animals, indicating the development of compensatory–adaptive reactions. In the kidneys, the area of the Shumlyansky–Bowman chamber decreases by 40.5% relative to the control group. It is shown that the application of the protective properties of selenium, which is contained in the composite, helps to reduce the toxicity of silver.

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Analysis of the Toxicity of a Cu2O Nanocomposite Encapsulated in a Polymer Matrix of Arabinogalactan

Cited by 2 publications

References 10 publications

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

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