Analysis of the Toxicity of Gadolinium Nanocomposites

Титов, Е. А.; Соседова, Л. М.; Новиков, М. А.

doi:10.1134/s1995078019020137

Cited by 4 publications

(3 citation statements)

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“…In recent studies, we did not reveal changes in the expression of caspase-3 and bcl-2 under the influence of iron oxide nanoparticles encapsulated in AG, while a decrease in the total number of neurons in the tissue of the sensorimotor cortex was observed, which makes it possible in this case to exclude the effect of apoptosis mechanisms on neuronal death [29]. Gadolinium nanoparticles on the AG matrix at a similar dose caused a decrease in the expression of bcl-2 in the rat brain [23], which is consistent with the results of Alarifi S. et al (2017) on the suppression of the expression of Bcl-2 mRNA when exposed to nanoparticles of gadolinium oxide Gd 2 O 3 on the culture of human neuroblastoma cells [30]. A decrease in the activity of this protein makes the cell more susceptible to apoptosis.…”

Section: Discussionmentioning

confidence: 86%

“…The deformation of the nuclei of neurons and an increase in the mitochondrial area revealed in this study, along with disturbances in the structure of the nervous tissue of the cerebral cortex, increased in the long term after exposure to nAG and may have a significant effect on the processes of intracellular metabolism. We recently showed that exposure to gadolinium nanoparticles encapsulated in a polymer matrix of AG leads to an increase in the number of degeneratively altered neurons and neuronophagy in the sensorimotor cortex in rats [23]. In addition, we established the selective cytotoxicity of copper oxide nanoparticles on the AG matrix, causing a decrease in astroglial cells, which can also lead to disruption of the normal homeostasis of the nervous tissue [24].…”

Section: Discussionmentioning

confidence: 98%

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Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Новиков

Титов

Соседова

et al. 2021

IJMS

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The aim of our investigation was to make a comparative assessment of the biological effects of silver nanoparticles encapsulated in a natural and synthetic polymer matrix. We carried out a comparative assessment of the biological effect of silver nanocomposites on natural (arabinogalactan) and synthetic (poly-1-vinyl-1,2,4-triazole) matrices. We used 144 three-month-old white outbred male rats, which were divided into six groups. Substances were administered orally for 9 days at a dose 500 μg/kg. Twelve rats from each group were withdrawn from the experiment immediately after nine days of exposure (early period), and the remaining 12 rats were withdrawn from the experiment 6 months after the end of the nine-day exposure (long-term period). We investigated the parietal–temporal area of the cerebral cortex using histological (morphological assessments of nervous tissue), electron microscopic (calculation of mitochondrial areas and assessment of the quality of the cell nucleus), and immunohistochemical methods (study of the expression of proteins regulating apoptosis bcl-2 and caspase 3). We found that the effect of the nanocomposite on the arabinogalactan matrix causes a disturbance in the nervous tissue structure, an increase in the area of mitochondria, a disturbance of the structure of nerve cells, and activation of the process of apoptosis.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 98%

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Новиков

Титов

Соседова

et al. 2021

IJMS

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“…В последние годы природный полимер арабиногалактан успешно используется в качестве носителя для доставки наночастиц в ткани и системы организма. Нами доказана возможность проникновения наночастиц серебра, инкапсулированных в матрицу арабиногалактана, в головной мозг белых крыс [16], что свидетельствует о способности молекул арабиногалактана преодолевать гематоэнцефалический барьер, что, в свою очередь, открывает возможность для прицельной доставки лекарственных препаратов в ЦНС. С этой точки зрения наноселен, инкапсулированный в матрицу арабиногалактана, является весьма перспективным соединением.…”

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Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan

Титов

Рукавишников

Соседова

et al. 2021

Acta biomedica scientifica

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Introduction. Due to their high biocompatibility, substances based on nanosized selenium particles, encapsulated in natural or synthetic polymer matrices, are promising materials for the creation of biomedical preparations of diagnostic and therapeutic value. Selenium nanoparticles are successfully used in the diagnosis of various types of cancer. In addition to the diagnostic value, selenium nanoparticles have their own prophylactic and oncological effect. This paper presents the results of a study of the toxicity of the Se nanocomposite encapsulated in the polymer matrix of arabinogalactan (SeAG). The emergence and development of the pathological process in the tissue of the brain, liver and kidneys during subacute administration of this nanocomposite was studied.Materials and methods. Twenty white outbred male rats weighing 200–220 g were used in the work. Animals were orally administered a solution of the selenium nanocomposite at a dose of 500 μg per kilogram of animal body weight for 10 days. Then, using the methods of histological analysis, the severity of the biological response of the organism to the introduction of this nanocomposite was assessed. An analysis of the state of the tissue of the liver, kidneys and the sensorimotor cortex of the brain was carried out.Results. With the intragastric administration of this drug, there is stasis of blood in the portal tracts, a pronounced macrophage reaction and diapedesis of leukocytes in the liver tissue. There is a decrease in the number of normal neurons per unit area, a decrease in the number of astroglia cells and an increase in the number of degeneratively altered neurons in the tissue of the sensorimotor cortex. There is also an increase in connective tissue in the cortex of the kidney, with the formation of fibrosis and a decrease in the area of the Shumlyansky – Bowman capsule.Conclusion. The effect of the investigated nanocomposite is characterized by the development of a pronounced pathological process in the central nervous and hepatorenal systems of the body.

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The impact of engineered nanomaterials on the environment: Release mechanism, toxicity, transformation, and remediation

Kumar

Karthick

Kumar

et al. 2022

Environmental Research

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Analysis of the Toxicity of Gadolinium Nanocomposites

Cited by 4 publications

References 8 publications

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Comparative Assessment of Silver Nanocomposites’ Biological Effects on the Natural and Synthetic Matrix

Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan

The impact of engineered nanomaterials on the environment: Release mechanism, toxicity, transformation, and remediation

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