Analysis of the Thermal Decomposition Products of Pathological and Healthy Tissues in Paranasal Sinuses: A High-Resolution Terahertz Gas Spectroscopy Study

Вакс, В. Л.; Aizenshtadt, Andrey; Anfertev, Vladimir; Chernyaeva, M. B.; Домрачева, Е. Г.; Gavrilova, K. A.; Larin, Roman; Приползин, С. И.; Шахова, М А

doi:10.3390/app11167562

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…The spectrometer with phase switching of radiation influencing gas [6] (the scheme is presented in Figure 1) has the radiation source generating the frequency of the signal for probing, a phase modulator modulating the frequency of the radiation source, a frequency synthesizer setting this frequency, and a personal computer (PC) controlling the frequency synthesizer. The detector receives the signal after transferring through the gas cell with the sample of gas under study and after interacting with the gas molecules.…”

Section: Methodsmentioning

confidence: 99%

“…However, to the best of our knowledge, there is no information in the database on the tissue metabolites of healthy and pathologically altered tissues. Our study of tissue metabolites in histologically verified material, taking into account comparison groups of apparently healthy tissue samples and pathology of the paranasal sinuses (cysts, polyps, and benign tumors), made it possible to identify patterns of changes in the metabolic profile and reveal certain chemical compounds as markers corresponding to a nosological unit or a group of diseases with similar biochemical structure [6]. Thus, the study of tissue metabolites aimed at creating a metabolic profile and identifying markers of pathologies or tissue diseases for medical diagnosis is an urgent task since it will reveal pathogenetic mechanisms of disease development, prospects for the clinical course, and enable assessment of the efficiency of therapy.…”

Section: Introductionmentioning

confidence: 99%

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Novel Approaches in the Diagnostics of Ear-Nose-Throat Diseases Using High-Resolution THz Spectroscopy

et al. 2023

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Nowadays, physicochemical methods of analysis are used in medical diagnostics. One can identify metabolites characteristic of a particular disease. The compilation of a metabolic profile will facilitate the diagnosis of diseases, evaluate their stage and etiology, and predict treatment. The goal of the study is to analyze the metabolite composition of the ear-nose-throat (ENT) tissues by high-resolution THz spectroscopy based on nonstationary effects and compare metabolites formed during the thermal decomposition of relatively healthy mucosa, polyps, and cysts. Studies were performed with the spectrometers operating from 118 to 178 GHz. The chemical compounds were identified using online catalogs. In all samples, there are such substances as methanol, propanediol, acetaldehyde, acetonitrile, butyronitrile, methyl mercaptan, azole, ethylene sulfide, carbon sulfide, and sulfur dioxide. In the spectrum of relatively healthy mucosa, the number of absorption lines of these substances is much less than in the spectrum of the polyps and cysts, which indicates their lower concentration. In the products of the polyps and cysts, acetone, hydroxyacetone, dihydroxyacetone, propionitrile, acrylonitrile, aminopropionitrile, hydroxyacetonitrile, aminoacetonitrile, methylbutironitrile, propanal, glycolaldehyde, lactaldehyde, and malone dialdehyde appear. The products of cysts’ thermal decomposition also contain acetic and acrylic acids. High-resolution THz spectroscopy has been shown to be promising for detecting disease metabolites in ENT tissues.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Approaches in the Diagnostics of Ear-Nose-Throat Diseases Using High-Resolution THz Spectroscopy

et al. 2023

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“…The generation of ultrashort pulses remains an important part in modern physics [1][2][3][4][5][6][7][8][9][10] due to the huge number of potential applications such as atomic clock measurements [11], astrophysics [12], distance metrology [13], frequency comb spectroscopy [14] and others [15][16][17]. Naturally it is rather complicated to create compact sources of THz and mid-IR (MIR) ultrashort pulses for systems of non-stationary spectroscopy [18], frequency metrology [19], time domain spectroscopy [20], nondestructive testing [21], etc. One of the most promising sources of THz and MIR radiation are quantum cascade lasers (QCLs) due to their high power, small spectral width and compactness [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Coherent mode locking in a two-section laser with fast gain and absorber

Arkhipov,

Diachkova,

Pakhomov

et al. 2024

Preprint

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Coherent mode locking is based on the formation of 2π pulses of self-induced transparency in the absorbing medium and π pulses in the amplifying medium. In this regime it becomes possible to generate ultrashort laser pulses down to one oscillation cycle with a pulse duration being much shorter than the polarization relaxation time T2 of the amplifying and absorbing medium. In this article a two-section laser model with a ring resonator based on absorbing and amplifying medium with short relaxation times has been applied. We have demonstrated a self-starting regime of coherent mode locking with picosecond and femtosecond laser pulses using numerical simulations for the given model. In addition, we have shown that there is a significant influence of generation frequency detuning on laser pulse duration and intensity. Moreover, we have compared our numerical results with an analytical model of a coherent mode-locked laser based on the area theorem. We believe that the findings of this work can open a pathway towards the practical application of mode locking in mid-IR and THz quantum cascade lasers.

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“…Приложения спектроскопии, направленные на анализ химического состава многокомпонентных смесей, широко применяются для решения задач медицинской диагностики [10][11][12][13][14][15][16], а также контроля качества продуктов питания [17,18], лекарственных препаратов [19,20] и сельскохозяйственной продукции.…”

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“…Чтобы выделить «быструю» часть спектра на обусловленном интерференцией «фоне», применяются методы модуляционной [23] и нестационарной [13,14]…”

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Simulation of the impact of the cell interference on the THz gas absorption spectrum meashured by nonstationar spectroscopy methods

Semenova¹,

Yablokov²,

Anfertev³

et al. 2022

JRE

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Cell is the important part of the terahertz (THz) spectrometer designed to study the chemical composition of multicomponent gas mixtures, since it is used for supporting the optimal pressure of the gaseous sample. However, the reflection of electromagnetic waves from the cell windows leads to standing-wave interference, which can distort the measured spectrum. Mathematical modeling of the impact of the interference on the measured spectrum was carried out in the paper. The cell was treated as a Fabry-Perot cavity with infinite flat dielectric mirrors. Diffraction of electromagnetic waves, as well as the frequency dependences of the source power and the detector sensitivity, was taken out of the scope of the considered model. The two effects of the interference were described. The interference not only determined the slow frequency dependence of the cell transmission spectrum, but also affected the profile of the gas absorption lines reconstructed from the cell spectrum in accordance with the Bouguer-Lambert-Beer law. Both the processing of the measured spectrum and the setup calibration required for accurate quantitative measurements could be complicated by the effects. However, methods of modulation and non-stationary spectroscopy enabled to eliminate the first effect, they were possibly ineffective to eliminate the second one. Presumably, the detected distortion of the contour of the absorption lines was caused by a shift in the interference pattern and, accordingly, a change in the reflection coefficient of the cell due to the anomalous dispersion of the sample. The correlation of the distortions with the derivatives of the transmission spectrum of the empty cell was revealed. The obtained results could be used to develop algorithms for calibrating the measuring setup and processing experimental data.

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Analysis of the Thermal Decomposition Products of Pathological and Healthy Tissues in Paranasal Sinuses: A High-Resolution Terahertz Gas Spectroscopy Study

Cited by 9 publications

References 14 publications

Novel Approaches in the Diagnostics of Ear-Nose-Throat Diseases Using High-Resolution THz Spectroscopy

Novel Approaches in the Diagnostics of Ear-Nose-Throat Diseases Using High-Resolution THz Spectroscopy

Coherent mode locking in a two-section laser with fast gain and absorber

Simulation of the impact of the cell interference on the THz gas absorption spectrum meashured by nonstationar spectroscopy methods

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