“…In male rats, tetanus 1 induced a significantly larger LTP, and the average increase in the mean slope level of the fEPSPs (% of baseline) induced by tetanus 1 in male rats was greater than that induced in female rats. Recent studies have indicated that the intracellular postsynaptic Ca 2 + rise and the subsequent synaptic plasticity is inflenced by the different tetani (Jager et al, 1998;Regehr and Tank, 1992), which lead to differential activation of different calcium channels (Grover and Teyler, 1990;Morgan and Teyler, 1999). Taken together, these data suggest that the interaction of gonadal hormones with Ca 2 + /NMDAR may underlie the effects of gonadal hormones on LTP.…”