Analysis of the state-of-the-art of consulting medical care to patients with glucocorticoid-induced osteoporosis or its risk according to the data of a questionnaire survey (GLUCOST study)

Баранова, И. А.; Ершова, О. Б.; Анаев, Э. Х.; Anokhina, T.N.; Аношенкова, О. Н.; Батын, С. З.; Belyaeva, E. S.; Беляева, Е. А.; Bolshakova, T Yu; Большакова, Т. Ю.; Волкорезов, И. А.; Елисеева, Л. Н.; Kashnazarova, E V; Kinyaikin, M.; Киняйкин, М. Ф.; Кирпикова, М. Н.; Klyuchnikova, E P; Ключникова, Е П; Королев, М. А.; Kuneevskaya, I V; Кунеевская, И В; Masneva, L V; Muradyants, A A; Мурадянц, А. А.; Оттева, Э. Н.; Petrachkova, T N; Peshekhonova, L K; Повзун, А С; Раскина, Т А; Smirnova, M L; Toroptsova, Nataliya Vladimirovna; Khasanova, R B; Шамсутдинова, Н. Г.; Шапорова, Н. Л.; С, Шитова Н; Shkireeva, S Yu; Shkireeva, S.; Na, Shostak; Шостак, Н. А.; Lesnyak, Olga; Лесняк, О. М.

doi:10.17116/terarkh201587558-64

Cited by 10 publications

(4 citation statements)

References 6 publications

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“…Baranova et al in a study on 1129 patients with chronic inflammatory diseases and a history of taking oral glucocorticosteroids for ≥ 3 months showed an increased probability of taking calcium and vitamin D supplements by 2.7-fold (95% CI; 2.1 to 3.5; p = 0.001). They also showed the increased likelihood of following treatment recommendations by 3.5-fold (95% CI; 2.3 to 5.3; p = 0.001) [54]. In parallel, in our study, a patient with a history of glucocorticosteroid use consumed more calcium supplement (11.9 vs 5.7, p < 0.001) and vitamin D supplement (11.4 vs 6.1, p < 0.001) (data not shown).…”

Section: Discussionmentioning

confidence: 96%

Prevalence of osteoporosis among the elderly population of Iran

et al. 2021

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In a large population-based study of Iran, the age-standardized prevalence of osteoporosis was 24.6% in men and 62.7% in women aged ≥ 60 years. Osteoporosis was negatively associated with body mass index in both sexes, and with diabetes in men and hypertriglyceridemia in women.Purpose Population aging has made osteoporosis and osteoporotic fractures an important health problem, especially in developing countries. This study aimed to explore the prevalence of osteoporosis and associated factors among the elderly population of the south-west of Iran. Methods Baseline data of the second stage of the Bushehr Elderly Health program was used. Spinal, total hip, or femoral neck osteoporosis was described as a BMD that lies 2.5 standard deviations or more, below the average values of a young healthy adult in the lumbar spine, total hip, or femoral neck, respectively. Osteoporosis at either site was defined as total osteoporosis. Agestandardized prevalence of osteoporosis was estimated. We used the modified Poisson regression with a robust variance estimator to identify the factors related to osteoporosis, adjusting for potential confounders. Results Overall, 2425 individuals (1166 men) aged over 60 years were included. In all, total osteoporosis was detected in 1006 (41.5%) of the participants. Using the reference value derived from Caucasian women aged 20-29 years, the age-standardized prevalence of total osteoporosis was 24.6 (95% CI: 21.9-27.3) in men, and 62.7 (95% CI: 60.0-65.4) in women. In men, osteoporosis was positively associated with age, smoking, history of fracture, and history of renal/liver diseases and negatively associated with body mass index (BMI) and diabetes. BMI, hypertriglyceridemia, and education were negatively correlated with osteoporosis in women, while years after menopause and history of fracture increased the likelihood of osteoporosis, significantly. Conclusion Results support the high prevalence of osteoporosis and osteopenia in the elderly population. Considering the importance of severe complications, especially fractures, comprehensive interventions should be expanded.

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Section: Discussionmentioning

confidence: 96%

Prevalence of osteoporosis among the elderly population of Iran

et al. 2021

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“…Полученные нами результаты согласуются с сообщениями других авторов о том, что снижение МПК связано с длительным применением ГК [16]. По данным Российского исследования ГЛЮКОСТ, включавшего 3347 пациентов с хроническими воспалительными заболеваниями, только 61,8% опрошенных, получавших ГК (вне зависимости от давности) знали об этом факторе риска переломов.…”

Section: Discussionunclassified

Osteopenic syndrome and chronic obstructive pulmonary disease among residents of lowland of the Kyrgyz Republic taking into account risk factors

Asanbaeva,

Lobanchenko,

Brimkulov

2024

Naučno-praktičeskaâ revmatologiâ

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The aim of the study was to identify the relationship between bone mineral density disorders and chronic obstructive pulmonary disease among residents of Bishkek, Kyrgyz Republic, taking into account risk factors.Material and methods. 200 residents of lowland (mean age 56,9±1,7 years) were examined. Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometry.Results. Chronic obstructive pulmonary disease (COPD) was almost 2-fold more common among patients with low BMD than healthy controls (63.0% and 34.8% of cases, respectively; p<0.001), despite the same frequency of smoking. Other independent predictors of low BMD were glucocorticoid intake and age.Conclusion. The occurence of COPD is an independent risk factor for the development of osteopenia/osteoporosis even after age and other known risk factors adjustment in lowland residents of the Kyrgyz Republic.

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“…All numerical data was expressed as mean ± standard deviation. For longitudinal repeated measurement data, repeated measures analysis of variance 31 was conducted to determine if (a) there was a “time effect” and (b) if there was a “time by group interaction effect”. The “time effect” indicates if there was a change over time for the examined variable, and the “time by group interaction effect” indicates if there were different change patterns over time among the examined groups.…”

Section: Methodsmentioning

confidence: 99%

Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis

Liu

et al. 2017

Sci Rep

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The underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly expressed CKIP-1 together with lowly expressed total and phosphorylated Smad1/5 in bone samples was accompanied by either the reduced serum bone formation markers in GIO patients or the decreased bone formation in GIO mice. In vitro studies showed that the highly expressed CKIP-1 could promote Smad1 ubiquitination to suppress the Smad-dependent BMP signaling and inhibit osteogenic differentiation and mineral deposition in MC3T3-E1 cells during glucocorticoid treatment. Further, the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 overexpression. Moreover, osteoblasts-targeting CKIP-1 siRNA treatment also attenuated the bone formation reduction in GIO mice. These study suggest that the highly expressed CKIP-1 in osteoblasts could suppress the Smad-dependent BMP signaling and contribute to the bone formation reduction in GIO. Targeting osteoblastic CKIP-1 would be a novel bone anabolic strategy for GIO patients.

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Analysis of the state-of-the-art of consulting medical care to patients with glucocorticoid-induced osteoporosis or its risk according to the data of a questionnaire survey (GLUCOST study)

Cited by 10 publications

References 6 publications

Prevalence of osteoporosis among the elderly population of Iran

Prevalence of osteoporosis among the elderly population of Iran

Osteopenic syndrome and chronic obstructive pulmonary disease among residents of lowland of the Kyrgyz Republic taking into account risk factors

Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis

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