Analysis of the South Australian Aboriginal population using the Global AIMs Nano ancestry test

Abstract

We investigate the ability of the 31 SNP loci in the Global AIMs Nano set to distinguish selfdeclared Australian Aboriginal individuals from European, Oceanic, African, Native American and East Asian populations. Human evolution suggests that Australian Aboriginal individuals came to Australia approximately 50 000 years ago, during the time it made up part of Sahul. Since then the colonisation of Australia by Europeans has meant significant admixture within the Australian Aboriginal population. These two events present themselves in our study with the Aboriginal population creating a continuous genetic cline between the Oceanic and European groups. We also assigned the Aboriginal individuals into their traditional regional groups to determine whether there was any ability to distinguish these from each other. We found similar results to studies using other markers, namely that the more remote regions (that have been less affected by admixture) diverged from the rest. Overall, we found the ability of the GNano system to differentiate self-declared Australian Aboriginal individuals was reasonable but had limitations that need to be recognised if these assignments are applied to unknown individuals.

Revisiting informed consent in forensic genomics in light of current technologies and the times

“…If not already obtained, it may be prudent, going forward, to obtain informed consent to use such samples. In contrast, some jurisdictions may interpret use of these samples obtained without informed consent is legally and/or ethically permissible (see [ 79 ] as an example of use of vulnerable population samples without informed consent, but legally permissible, for research and validation studies).…”