Analysis of the short‐term effect of two viscoelastic agents on the intraocular pressure after extracapsular cataract extraction

Storr‐Paulsen, Allan

doi:10.1111/j.1755-3768.1993.tb04985.x

Cited by 16 publications

(2 citation statements)

References 12 publications

(17 reference statements)

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“…Moreover, no adverse effect during non-ocular surgeries has been observed. 15 With respect to the endothelium, no significant change in intraocular pressure was observed capable of modifying corneal hydration during cataract extracapsular surgery 16 and its efficiency to prevent swelling and endothelial cell damage induced by the surgery has been confirmed. 17,18 In the present study, we propose the use of HPMC 2% as an alternative to ensure a good preservation of the tissue without modifying the water content of the cornea, during performing any mechanical test that may imply an alteration of the corneal structure.…”

Section: Discussionmentioning

confidence: 99%

Use of 2% hydroxypropyl methylcellulose to prevent the corneal swelling during the in vitro mechanical characterization

Ortillés

Lanchares

Cristobal

et al. 2017

Proceedings of the Institution of Mechanical Engineers, Part L:

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The purpose of this study was to establish adequate conditions for the storage and handling of the corneal tissue destined to be in vitro tested for the characterization of the mechanical properties. Twenty-eight rabbit eyes were divided into 4 groups. Group A (7 eyes) 24 hours preserved in refrigerated (4ºC) NaCl 0.9% solution before testing. Group B (7 eyes) immediately tested. In both groups, to prevent both swelling and dehydration, a preparation of hydroxypropyl methylcellulose 2% (HPMC 2%) was applied. Group C (7 eyes) 24 hours preserved in refrigerated (4ºC) NaCl 0.9% solution before testing. Group D (7 eyes) immediately tested. In both groups, preparation of HPMC 2% was not applied. Regarding the mechanical response, groups A and B (handled with HPMC 2%) showed similar Cauchy stress-stretch curves and there were no statistically significant differences at 5%, 10% and 15% strain between them, which means that both showed similar mechanical behavior. The same result was obtained between groups C and D (without HPMC 2%). However, for coupled groups AB (with HPMC 2%) and CD (without HPMC 2%) statistically significant differences at 10% and 15% strain were observed. On the other hand, when grouped by storage time, statistically significant differences were found between groups A and C (24 hours stored with and without HPMC 2%, respectively), as well as between groups B and D (immediately tested with and without HPMC 2%, respectively) at 15% strain. Nevertheless, if coupled groups were considered, between groups AC (24 hours in NaCl 0.9% before tested) and BD (immediately tested) no statistically significant differences were obtained. In addition, the Cauchy stress-stretch curves of groups without HPMC 2% showed a decreasing slope of the linear part (strain > 8%) of the graph during the experiment. In the author´s opinion, this fact could be due to some level of swelling happened in those samples during handling or mechanical testing. In summary, the use of a preparation of HPMC 2% during the handling of the tissue from excision to testing seems to prevent both swelling and dehydration. Moreover, cold storage of the eye in NaCl 0.9% solution for 24 hours before testing does not modify the mechanical response.

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Section: Discussionmentioning

confidence: 99%

Use of 2% hydroxypropyl methylcellulose to prevent the corneal swelling during the in vitro mechanical characterization

Ortillés

Lanchares

Cristobal

et al. 2017

Proceedings of the Institution of Mechanical Engineers, Part L:

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“…OVD which is used for insertion of the IOL into the lens capsule can be trapped behind the IOL. A common complication of OVDs after cataract surgery is an increase in postoperative intraocular pressure (IOP) because of OVD remaining in the lens capsule or the anterior chamber and obstructing the trabecular meshwork [ 1 – 6 ]. Since IOP spikes could cause the damage of the optic nerve and visual disturbance in the patients with glaucoma, ophthalmic surgeons should avoid IOP spikes after cataract surgery.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a new method of irrigation and aspiration for removal of ophthalmic viscoelastic device during cataract surgery in a porcine model

et al. 2014

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BackgroundTo determine if a method for irrigation and aspiration (I/A) during cataract surgery provides effective removal of ophthalmic viscoelastic device (OVD).MethodsJapanese porcine eyes were used to evaluate I/A performance with Technique 1 (the I/A tip placed on the center of the anterior surface of the IOL), Technique 2 (the I/A tip alternately pressed near the edge of the IOL optic anterior surface on one side and then the other to tilt the IOL back and forth), and Technique 3 (the I/A tip inserted behind the IOL optic, between it and the posterior capsule). Techniques 1 and 2 were compared using the Miyake-Apple posterior view video technique to visualize the flow of irrigation fluid containing triamcinolone acetonide particles behind the IOL. To check the efficacy of OVD removal from behind the IOL for of all three I/A techniques, OVD with fluorescein beads were inserted inside the lens capsule before implantation of the IOL. After each I/A technique, eyes were prepared for Miyake–Apple viewing and pictures of the lens capsule were taken using fluorescent microscopy. Residual fluorescein beads in the capsular bag were analyzed.ResultsTechnique 1 resulted in a straight flow of fluid behind the IOL, while Technique 2 resulted in a vortex flow. The average amount of OVD retained inside the capsule after using Technique 2 or 3 was significantly lower than after using Technique 1 (p <0.0001).ConclusionsTechnique 2 proved to remove more effectively fluorescein bead-labelled OVD under the IOL than Technique 1.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2415-14-129) contains supplementary material, which is available to authorized users.

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Small Incision Cataract Surgery and Glaucoma

Poley

Lindstrom

Samuelson

et al. 2009

Cataract Surgery in the Glaucoma Patient

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Analysis of the short‐term effect of two viscoelastic agents on the intraocular pressure after extracapsular cataract extraction

Cited by 16 publications

References 12 publications

Use of 2% hydroxypropyl methylcellulose to prevent the corneal swelling during the in vitro mechanical characterization

Use of 2% hydroxypropyl methylcellulose to prevent the corneal swelling during the in vitro mechanical characterization

Evaluation of a new method of irrigation and aspiration for removal of ophthalmic viscoelastic device during cataract surgery in a porcine model

Small Incision Cataract Surgery and Glaucoma

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