Analysis of the seroprevalence of and factors associated with Chagas disease in an endemic area in Northeastern Brazil

Filho

Rocha

et al. 2018

Self Cite

Introduction: The transmission of Chagas disease (CD) through blood transfusion, organ transplantation, and oral transmission has gained greater visibility as a result of intensified vector control activities in endemic regions and to control CD in nonendemic regions. In Brazil, Ceará is one of the states that perform the most organ transplants. Therefore, the objective of this study was to assess the prevalence of Trypanosoma cruzi infection in organ donor candidates. Methods: A retrospective analysis was performed on data from potential organ donors at the Center of Transplantation of the State of Ceará from 2010-2015. Results: Data from a total of 2,822 potential donors were obtained, of which 1,038 were effective donors and 1,784 were excluded, likely due to lack of family authorization or medical contraindication. The prevalence of T. cruzi infection among these potential donors was 1.3% (n = 29). The majority of infected donors were males aged 41-60 years, residing in the interior of the state. Interestingly, 72.4% (n = 21) had positive or inconclusive serology for additional infections, such as cytomegalovirus, hepatitis B and C, and toxoplasmosis. Probability analysis revealed that stroke was the most common cause of death among potential donors with CD. Conclusions: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased risk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.

Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil

Filho

Rocha

et al. 2018

Self Cite

“…Freitas et al 27 reported that R. nasutus specimens occur in households more frequently during the period when carnauba trees are pruned and suggested that anthropogenic environmental degradation contributes to the domiciliation of triatomines and facilitates vector transmission of Chagas disease in the municipality of Limoeiro do Norte.…”

Section: Triatomine Collectionmentioning

confidence: 99%

Insect vectors of Chagas disease (Trypanosoma cruzi) in Northeastern Brazil

Fidalgo

Filho

et al. 2018

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“…A high prevalence of Chagas disease (CD) has been observed in the state of Ceará (14.8%) since the first studies performed by Alencar, particularly in the municipality of Limoeiro do Norte 5 . In this municipality, estimated seroprevalence rates of 2.6% (4/154) and 4.2% (34/812) were observed in 2011 and 2013, respectively 6,7 . This region presents a high risk of vectorial transmission due to the high rate of natural infection by T. cruzi (estimated in 7.9%) in triatomines 8 .…”

mentioning

confidence: 75%

Seroprevalence and risk factors of Chagas disease in a rural population of the Quixeré municipality, Ceará, Brazil

Fidalgo

Ramos

et al. 2021

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Introduction: This study estimated the seroprevalence and risk factors of Chagas disease (CD) in a population of the Quixeré municipality, Ceará. Methods: We conducted serological methods to detect the Trypanosoma cruzi infection. The other variables were evaluated by a standardized questionnaire. Results: The estimated prevalence of CD was 3.7%. Male sex, age >40 years, being farmers, low education level, origin from rural areas, and being born in Quixeré were significantly associated with infection. Conclusion: CD persists in this rural population of Northeast Brazil. Poverty, low education, and limited information regarding CD are critical issues that need to be addressed.