“…Glycan processing involves trimming of glucose and mannose residues and subsequent addition of various terminal sugars resulting in different classes of glycans, including high mannose, hybrid and complex N-glycans [ 28 , 32 ]. Functional and structural studies on N-linked glycans from several viral fusion proteins, including influenza hemagglutinin [ 33 , 34 ], coronavirus spike protein [ 35 , 36 , 37 , 38 ], Ebola virus glycoprotein GP [ 39 ], envelope glycoprotein (Env) of human immunodeficiency virus-1 (HIV-1) [ 40 , 41 ], or envelope (E) protein of the flaviviruses Zika [ 42 ] and Dengue virus [ 43 ] have shown that these structures can play diverse functional and structural roles, e.g., in immune evasion by shielding from neutralizing antibodies, enhancement of infection, or stability and maturation of the respective fusion protein.…”