“…In addition to the important role of the extracellular domain of ICAM-1, the intracellular domain also plays a pivotal role in leukocyte transendothelial migration (TEM), but has no catalytic activity (Sans et al, 2001;Greenwood et al, 2003). After ICAM-1 cross-linking or coculture with leukocytes, endothelial ICAM-1 initiates intracellular calcium flux and cytoskeletal signal transduction events, including activation of Rho GTPase and phosphorylation of cortactin, paxillin, p130 cas , and focal-adhesion kinase (DurieuTrautmann et al, 1994;Etienne et al, 1998;Adamson et al, 1999;Thompson et al, 2002).…”