Analysis of the risk of complications during pregnancy in pregnant women with assisted reproductive technology: a retrospective study using registry linkage from 2013 to 2018 in Shanghai, China

He, Miao; Sun, Xiaoxi; Wang, Chunfang; Sui, Yilun

doi:10.1186/s12884-022-04846-1

Cited by 19 publications

(13 citation statements)

References 42 publications

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“…To date, only few studies have investigated neonatal outcomes in GDM women conceiving with ART. It's known that both ART 25 and GDM 26 may increase the risk of adverse pregnancy outcomes. Aside from the direct effect of multiple pregnancies, the metanalysis of Qin et al 1 .…”

Section: Discussionmentioning

confidence: 99%

“…To only few studies have investigated neonatal outcomes in GDM women conceiving with ART. It's known that both ART 25 and GDM 26 may increase the risk of adverse pregnancy outcomes. Aside from the direct effect of multiple pregnancies, the metanalysis of Qin et al 1 indicated an increased risk of preterm delivery in singleton pregnancies conceived by ART compared to SC(RR 1.71, 95% CI 1.59-1.83).…”

Section: Multivariatementioning

confidence: 99%

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Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Bianchi

Brocchi

Baronti

et al. 2023

Diabetes Metabolism Res

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Aims To evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. Materials and Methods We retrospectively collected clinical and anthropometric data of 219ART‐ and 256 age‐ and body mass index (BMI)‐matched women with spontaneous conception screened for GDM. The primary outcome was to evaluate GDM prevalence in ART women. Results There were no differences in age, BMI, and family history of diabetes in the two groups of women. ART‐women were more frequently primiparous, whereas the prevalence of previous GDM was higher in SC‐women. The prevalence of GDM in the whole cohort was 36.1% and was higher in ART‐women (52.3% vs. 23.4%; p < 0.0001). In the whole cohort, on multivariate analysis, family history of diabetes (OR 1.67; 95% CI: 1.03–2.69), previous GDM (OR 7.05; 95% CI: 2.92–17.04), pre‐pregnancy obesity (OR 2.72; 95% CI 1.21–6.13), and ART (OR 4.14; 95% CI 2.65–6.48) were independent risk factors for GDM. Among ART‐women, age over 40 years was associated with GDM. Preterm delivery was more common in ART‐women; gestational week at delivery, birth weight, ponderal index, and Apgar score were lower in ART‐women than in SC‐women, both in the whole cohort and in GDM women. Conclusions Among women undergoing ART treatment, at least one in two develops GDM. ART appears to be an independent risk factor for GDM in single pregnancies, particularly above the age of 40. ART treatment seems to be associated with an increased rate of preterm delivery and lower neonatal birth weight and Apgar score, especially in GDM women. Clinical Trial Registration The study was not registered as it is an observational retrospective evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Multivariatementioning

confidence: 99%

Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Bianchi

Brocchi

Baronti

et al. 2023

Diabetes Metabolism Res

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“…A series of evidence in recent years suggests frozen embryo transfer could bring better pregnancy outcomes by avoiding excess physiological hormone exposure than fresh embryo transfer ( 25 , 26 ). Although the database does not record the information on transferred embryos, a former cohort study in Shanghai reported that frozen embryo transfer accounted for 68.3% (4,071/5,960) from 2013 to 2018 ( 27 ). A former study compared pregnancy outcomes between different controlled ovulation stimulation protocols in IVF ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

A mutual comparison of pregnancy outcomes between different conception modes: a propensity score matching based retrospective cohort study

Sun,

Sheng,

Huang

2024

Front. Endocrinol.

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BackgroundAssisted reproductive technology (ART) has been reported to have negative effects on maternal and neonatal health. Ovulation induction (OI) was reported to be associated with alteration of epigenetic modification of mice embryos, and extinguishing the influence of ovulation induction and in vitro operations on maternal and neonatal health will bring benefits for reducing side effects. The present study aimed to determine whether ovulation induction alone and ART are associated with adverse pregnancy outcomes and whether ART could induce a higher risk than ovulation induction alone.MethodsA total of 51,172 cases with singleton live birth between Jan 2016 and May 2019 at the International Peace Maternal and Child Health Hospital were included in this study. Conception modes documented during registration were classified into natural conception (NC), OI, and ART. Pregnancy outcomes of the three groups with balanced baseline characteristics by propensity score matching were compared. The relative risks of maternal and neonatal outcomes were calculated by logistic regression analysis.ResultsCompared with natural conception, infertility treatments are associated with gestational diabetes (OI: OR 1.72, 95% CI 1.31-2.27; ART: OR 1.67, 95% CI 1.26-2.20), preeclampsia/eclampsia (OI: OR 1.86, 95% CI 1.03-3.36; ART: OR 2.23, 95% CI 1.26-3.92). Even if gestational diabetes, gestational hypertension, and placental problems were adjusted, infertility treatments are associated with birth before 37 weeks (OI: OR 1.99, 95% CI 1.28-3.12; ART: OR 1.70, 95% CI 1.08-2.69), low birth weight (OI: OR 2.19, 95% CI 1.23-3.91; ART: OR 1.90, 95% CI 1.05-3.45), and SGA (OI: OR 2.42, 95% CI 1.20-4.87; ART: OR 2.56, 95% CI 1.28-5.11). ART but not OI is associated with a higher risk of birth before 34 weeks (OR:3.12, 95% CI 1.21-8.05). By comparing the OI group with the ART group, we only found that ART could induce a higher ratio of placental problems (5.0%, 26/518 vs 2.1%, 11/519, p<0.05).ConclusionBoth OI and ART are associated with adverse pregnancy outcomes. ART induced comparable negative effects with OI on gestational complications, birth weight, and premature birth (<37 weeks). However, ART resulted in a higher risk of placental problems than group NC and OI. The incidence of birth before 34 weeks of gestation in the ART group tends to be higher than in the OI group, but not statistically significant. The side effects of ART may originate from OI.

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“…IVF is associated with an increased risk of complications like hypertension, gestational diabetes mellitus, prematurity, and other perinatal complications [ 8 , 9 ]. Hypertension-related complications can affect the mother and the fetus and are observed in 2-3% of pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Incidence of complications among in vitro fertilization pregnancies

Tocariu,

Stan,

Mitroi

et al. 2023

JMedLife

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The use of assisted reproductive technology has increased in Romania in the past several years. Although most of these pregnancies are uncomplicated, in vitro fertilization is associated with an increased risk for adverse perinatal outcomes primarily caused by the increased risks of prematurity, gestational diabetes mellitus, and hypertensive disorders. Infertility can be caused by a variety of factors, including both male and female factors, and in some cases, the cause remains unknown. In our clinic, the etiology of infertility was known in most cases and was equally distributed between male and female factors. Women with gestational hypertension were significantly older. Patients with twin pregnancies were significantly younger than those with a single pregnancy. The prevalence of preterm newborns was 2.5 times higher than the global prevalence for prematurity.

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Analysis of the risk of complications during pregnancy in pregnant women with assisted reproductive technology: a retrospective study using registry linkage from 2013 to 2018 in Shanghai, China

Cited by 19 publications

References 42 publications

Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies

A mutual comparison of pregnancy outcomes between different conception modes: a propensity score matching based retrospective cohort study

Incidence of complications among in vitro fertilization pregnancies

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