Analysis of the risk factors for central lymph-node metastasis of cN0 papillary thyroid microcarcinoma: A retrospective study

Li, Jun; Fan, Xueliang; Yang, Meng; Huang, Li

doi:10.1016/j.asjsur.2021.09.014

Cited by 10 publications

(12 citation statements)

References 29 publications

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“…Consequently, the current study might be the first to show that the male sex is associated with an additional 2.7-fold risk of malignant disease. Liu et al (16) analyzed the risk factors for central lymph node metastasis in cN0 PTC and found that the male sex was an independent predictor with an odds ratio (OR) of 5.6. Recently, Zuhur et al (17) confirmed the prognostic significance of male sex in differentiated thyroid carcinoma and reported that according to the American Thyroid Association low-risk category, male sex predicted a markedly shorter diseasefree survival.…”

Section: Discussionmentioning

confidence: 99%

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Predictors of Malignancy in Thyroid Nodules Classified as Bethesda Category III

Liu

Wang

et al. 2022

Front. Endocrinol.

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ObjectiveTo determine predictors of malignancy in surgically treated Bethesda category III nodules.MethodsPatients with surgically treated thyroid nodules classified as Bethesda category III were retrospectively enrolled. The association between clinical/sonographic features and postoperative pathology was evaluated using univariate and multivariate analyses.ResultsA total of 188 nodules from 184 patients were included. The overall malignancy rate was 54.3%. In univariate analysis, male sex, aspect ratio >1, microcalcification, unclear boundary, BRAFV600E mutation, and nuclear atypia were significantly associated with malignant disease in Bethesda category III nodules. Multivariate analysis confirmed that male sex, aspect ratio >1, microcalcification, and BRAFV600E mutation were independent predictors of malignant disease.ConclusionsMalignant disease was common in Bethesda category III nodules, and surgical treatment was strongly indicated in the presence of male sex, aspect ratio>1, microcalcification, and BRAFV600E mutation.

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Section: Discussionmentioning

confidence: 99%

“…Liu et al. ( 16 ) analyzed the risk factors for central lymph node metastasis in cN0 PTC and found that the male sex was an independent predictor with an odds ratio (OR) of 5.6. Recently, Zuhur et al.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Malignancy in Thyroid Nodules Classified as Bethesda Category III

Liu

Wang

et al. 2022

Front. Endocrinol.

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“…In our cohort, there was a statistical association between tumor size and LNM, in which larger PTMC had a higher incidence of LNM and CLNM, but not LLNM. Li et al 24 analyzed 273 PTMC patients with clinically negative central lymph nodes, which showed a large tumor diameter had a strong correlation with a larger number of CLNM. Feng et al 11 did a study including 785 PTMC patients who underwent thyroidectomy and CLND and showed the incidence of CLNM was 18.9% in smaller PTMC and 42.7% in larger PTMC, similar to our results.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Findings Associated With Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study in China

et al. 2022

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Objective The incidence of papillary thyroid microcarcinoma (PTMC) has increased sharply during the past decades. Yet, whether or not nodal dissection should be performed remains controversial. This article aims to assess the high-risk factors associated with cervical lymph node metastasis (LNM) in patients with PTMC, which may potentially guide clinical management decision-making. Methods Medical records of 449 PTMC patients who underwent thyroidectomy in our hospital from August 2016 to July 2017 were retrospectively reviewed. Clinical and pathological factors of the patients were anonymously extracted from the charts and analyzed. Result The patients were classified into two subgroups according to maximum tumor size measured through post-surgical pathology: smaller PTMC group (≤5 mm) and larger PTMC group (>5 mm). Larger tumor size was found to be associated with a higher rate of LNM ( P = .001), particularly central lymph node metastasis (CLNM) ( P = .001). Tumor size was also associated with extrathyroidal tumor extension (ETE) ( P < .001), bilateral lesions ( P = .015), and BRAFv600e mutation ( P = .004). LNM was found to be more common in older patients (>55 y) ( P = .030), and those with multifocal cancer ( P < .001). In PTMC patients with unilateral lesions without ETE, tumor size was not significantly associated with LNM ( P = .121). Conclusions For the PTMC population, tumor size was an independent risk factor for LNM, particularly for patients of old age (>55 y), and multifocality. However, in PTMC patients with unilateral lesions without extrathyroidal extension, tumor size was not related to the risk of LNM. These findings may potentially guide clinical decision-making in terms of cervical nodal dissection.

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“…Thyroid carcinoma is the most common malignant tumor of the endocrine system, and it has been increasingly studied by clinicians and researchers. In the past years, its incidence has gradually increased, with the fastest increase observed among all types of malignant tumors [ 1 ]. Specifically, in terms of pathological type of thyroid carcinoma, there has been a growing incidence of papillary carcinoma, while in terms of pathological stage microcarcinoma has exhibited the fastest increase in incidence [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Ultrasonographic Appearance of Papillary Thyroid Microcarcinoma and BRAF V600E Mutation

Liang

Huang

2022

Journal of Oncology

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The study was conducted to investigate the correlation between the ultrasonographic appearance of a thyroid nodule and the BRAF V600E mutation. Patients with thyroid nodules ( n = 186 ), for which BRAF V600E testing and cytopathology analysis were performed, and who underwent subsequent surgery for nodule resection were enrolled in this study. For each patient, color Doppler ultrasonography was performed to observe the variables of the nodules. The nodules were then characterized using the thyroid imaging reporting and data system classification TI-RADS. Furthermore, the ultrasonographic appearance of the control group, encompassing patients with nodular thyroid goiters, and the case group, encompassing patients with papillary thyroid microcarcinoma (PTMC), was statically analyzed. Similarly, a statistical analysis of the ultrasonographic appearance of the BRAF V600E-positive and BRAF V600E-negative subgroups was also performed. The accuracy was significantly different for the corresponding values when color Doppler ultrasonography, BRAF V600E testing, or cytopathology alone was used for diagnosis. There were significant differences in the ultrasonographic appearance variables between the control and case groups. Comparing with the BRAF V600E-negative subgroup of the case group, the ultrasonographic appearances of the BRAF V600E-positive subgroup showed less circumscribed and more irregularly shaped nodules, with significantly different aspect ratios of >1. The combination of BRAF V600E testing and color Doppler ultrasonography or cytopathology improved the accuracy of the PTMC diagnose. We found that the ultrasonographic appearance of thyroid nodules was related to PTMC.

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Analysis of the risk factors for central lymph-node metastasis of cN0 papillary thyroid microcarcinoma: A retrospective study

Cited by 10 publications

References 29 publications

Predictors of Malignancy in Thyroid Nodules Classified as Bethesda Category III

Predictors of Malignancy in Thyroid Nodules Classified as Bethesda Category III

Clinicopathological Findings Associated With Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study in China

Correlation between Ultrasonographic Appearance of Papillary Thyroid Microcarcinoma and BRAF V600E Mutation

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