Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Zheng, Xiao-fen; Tian, Jun-Sheng; Liu, Peng; Xing, Jie; Qin, Xuemei

doi:10.1016/j.jep.2013.12.001

Cited by 74 publications

(41 citation statements)

References 35 publications

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“…The SDS models had been well established according to the requirement of different studies. In details, the spleen Yang deficiency model could be established by single factor methods such as injecting hydrocortisone and gavaging Sennae Folium or by compound factors way such as gavaging adenine, improper diet and exhaustion (Pan et al, 2014) whereas the spleen Qi deficiency model could be conducted by oral administration of Radix Rhei extract as well as the loaded swimming and starvation for 24 hours (Zheng et al, 2014;Tian et al, 2015;Chen et al, 2014a;Liu and Shi, 2015). As for hepatic tumor model, the most common used approaches for orthotopic transplantation HCC model were intravenous, intrasplenic, intrahepatic inoculation of tumor cells and intrahepatic tissue implantation, of which the orthotopic intrahepatic tissue implantation was regarded as the favorable approach (Rao et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

). Establishment and Evaluation of the Orthotopic Hepatocellular Carcinoma and Drug-Induced Hepatocellular Carcinoma in Mice With Spleen-Deficiency Syndrome in Traditional Chinese Medicine

Hy¹,

Chen²,

Sun³

et al. 2016

AJTCAM

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Background: Spleen-deficiency syndrome (SDS) in Traditional Chinese Medicine (TCM) played pivotal roles on the development of hepatocellular carcinoma (HCC). This study was performed to establish and evaluate HCC model in mice with SDS in TCM. Material and Methods: A total of 90 C57BL/6 mice were randomized in six groups (n=15 for each group): A, Control group; B, SDS group; C, orthotopic HCC (OHCC) group; D, OHCC based on SDS (SDS-OHCC) group; E, Druginduced HCC (DHCC) group; F, DHCC based on SDS (SDS-DHCC) group. The SDS model were established by subcutaneous injection of reserpine, followed by the OHCC or DHCC model establishment. The SDS scores, tumor formation rate and survival time were recorded and calculated, as well as the histochemical stain was performed. Conclusion:The SDS-oriented HCC mice models were simple and easily-operated models for further studies on SDS oriented tumor. Meanwhile, SDS was a pivotal factor for low outcome of hepatic tumor.

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Section: Introductionmentioning

confidence: 99%

). Establishment and Evaluation of the Orthotopic Hepatocellular Carcinoma and Drug-Induced Hepatocellular Carcinoma in Mice With Spleen-Deficiency Syndrome in Traditional Chinese Medicine

Hy¹,

Chen²,

Sun³

et al. 2016

AJTCAM

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“…This formula has been reported to produce clear benefits and good results in patients with muscle weakness and is even used in PM practically. 5,6 In addition, SJZT can be used as a tonic supplement for refractory PM and alleviate the adverse effects of Western medicine. 7 Our results showed that muscle power was recovered within 1 month of additional TCM treatment.…”

Section: Discussionmentioning

confidence: 99%

Combination Therapy of Traditional Chinese Medicine and Western Medicine to Treat Refractory Polymyositis: A Case Report

Cheng

Tsai

Chen

et al. 2015

The Journal of Alternative and Complementary Medicine

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“…Zheng et al. evaluated the restorative effects of Bu‐Zhong‐Yi‐Qi‐tang in the spleen Qi deficiency rat model using 1 H NMR spectroscopy based metabolomics and identified four potential metabolites of spleen Qi deficiency . In this sense, metabolomics provides a novel perspective on the search for markers of symptoms and the mechanism of TCM.…”

Section: Introductionmentioning

confidence: 99%

Application of pathways activity profiling to urine metabolomics for screening Qi‐tonifying biomarkers and metabolic pathways of honey‐processed Astragalus

Liu

Huang

et al. 2018

J of Separation Science

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Honey-processed Astragalus, a widely used Qi-tonifying and immunomodulating herb in traditional Chinese medicine, has strengthened the tonic effects and achieved fewer side effects compared with astragali radix in clinical application. Here, we focus on Qi-tonifying biomarkers and pathways of honey-processed Astragalus using urine metabolomics that provide the basis for building the linkage between metabolites in rat urine and its symptoms. The spleen Qi deficiency model group, normal group, astragali radix group, and honey-processed Astragalus group were implemented to evaluate Qi-tonifying effects. Twelve potential biomarkers were screened by multivariate statistical analysis by using ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Furthermore, pathways activity profiling showed unique pathways that are primarily involved in tryptophan metabolism, tricarboxylic acids cycle, and methionine metabolism. The results demonstrated that metabolomics coupled with pathway activity profiling were promising tools. It might serve as a novel methodological clue to systematically dissect the underlying Qi-tonifying mechanism of honey-processed Astragalus.

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Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H-NMR-based metabonomics

Cited by 74 publications

References 35 publications

). Establishment and Evaluation of the Orthotopic Hepatocellular Carcinoma and Drug-Induced Hepatocellular Carcinoma in Mice With Spleen-Deficiency Syndrome in Traditional Chinese Medicine

). Establishment and Evaluation of the Orthotopic Hepatocellular Carcinoma and Drug-Induced Hepatocellular Carcinoma in Mice With Spleen-Deficiency Syndrome in Traditional Chinese Medicine

Combination Therapy of Traditional Chinese Medicine and Western Medicine to Treat Refractory Polymyositis: A Case Report

Application of pathways activity profiling to urine metabolomics for screening Qi‐tonifying biomarkers and metabolic pathways of honey‐processed Astragalus

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