Analysis of the relationship between insulin-like growth factor 1 receptor gene polymorphisms in Montbeliarde cows and the birth weight of their calves

Szewczuk, M.

doi:10.2754/avb201685010041

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…It is worth noting that various expression levels of IGF1 may result from DNA mutations and differences in single nucleotide polymorphisms (SNPs) prevalence between the examined breeds. Previous studies have shown the effect of the SNP of the IGF-1 gene on the growth rate and meat production traits in beef cattle such as: Limousin and Hereford [ 46 ], Angus [ 47 , 48 ], Montbeliarde [ 49 ], and Hanwoo [ 50 ]. It is possible that the higher igf-1 expression level in LIM and HER bulls compared with HF further contributes to achieving higher muscle mass growth in typical beef breeds.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls

Ciecierska

Motyl

Sadkowski

2020

IJMS

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The aim of the study was to identify differences in the transcriptomic profiles of primary muscle cell cultures derived from the semitendinosus muscle of bulls of beef breeds (Limousin (LIM) and Hereford (HER)) and a dairy breed (Holstein-Friesian (HF)) (n = 4 for each breed). Finding a common expression pattern for proliferating cells may point to such an early orientation of the cattle beef phenotype at the transcriptome level of unfused myogenic cells. To check this hypothesis, microarray analyses were performed. The analysis revealed 825 upregulated and 1300 downregulated transcripts similar in both beef breeds (LIM and HER) and significantly different when compared with the dairy breed (HF) used as a reference. Ontological analyses showed that the largest group of genes were involved in muscle organ development. Muscle cells of beef breeds showed higher expression of genes involved in myogenesis (including erbb-3, myf5, myog, des, igf-1, tgfb2) and those encoding proteins comprising the contractile apparatus (acta1, actc1, myh3, myh11, myl1, myl2, myl4, tpm1, tnnt2, tnnc1). The obtained results confirmed our hypothesis that the expression profile of several groups of genes is common in beef breeds at the level of proliferating satellite cells but differs from that observed in typical dairy breeds.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls

Ciecierska

Motyl

Sadkowski

2020

IJMS

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“…Several studies on the IGF-1R gene have been reported in mammals (Kawashima et al, 2005;Proskura and Szewczuk, 2014;Szewczuk, 2016). When Lei et al (2008) studied the associations of the IGF-1R gene with chicken early growth and carcass traits in the Xinghua and White Recessive Rock chickens, they found that six SNPs (C17445985T, G17445596A, A17307750G, A17307494G, A17299834G, and C17293932T) were possibly associated with growth traits.…”

Section: Correlation Analysis Between Igf-1r Gene and Growth Traitsmentioning

confidence: 99%

Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens

Peng¹,

Wang

Jin³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Growth traits are important economic traits in broiler chicken production. AluI and Hin1I loci are two restriction sites, which are respectively located in exons 2 and 3 of the IGF-1R gene. These two loci are significantly related to the growth traits in Jinghai Yellow chickens. In this study, a correlation analysis was performed between these two loci and the growth traits of Bian chickens. The results showed a G376A mutation at the AluI site and a C919A mutation at the Hin1I site, which respectively resulted in three genotypes AA, AB, and BB in exon 2 and three genotypes CC, CD, and DD in exon 3. Correlation analysis showed that the female Bian chickens with the AA genotype of the AluI locus had higher body weights than those with the 2 P.F. Wu et al. Genetics and Molecular Research 16 (2): gmr16029619AB genotype (P < 0.05) at 8, 14, 16, and 18 weeks; individuals with CD genotype of Hin1I locus had higher body weights at 6, 8, 10, 12, and 14 weeks compared to the CC genotype (P < 0.05 or P < 0.01). Combined genotypes analysis showed that at the age of 8, 14, 16, and 18 weeks, the body weight of AACC genotype combination was higher than that of the ABCC genotype combination (P < 0.05); at the age of 6, 8, 12, 14, 16, and 18 weeks, the AACD genotype combination had higher (P < 0.05 or P < 0.01) body weight than that of the ABCC genotype.

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Analysis of the relationship between insulin-like growth factor 1 receptor gene polymorphisms in Montbeliarde cows and the birth weight of their calves

Cited by 2 publications

References 23 publications

Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls

Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls

Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens

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