Analysis of the relationship between Oxford classification,IgM deposition and multiple indexes and the adverseprognosis of patients with primary IgA nephropathy and related risk factors

Abstract

The risk and influencing factors of prognosis in patients with primary IgA nephropathy (IgAN) were explored. One hundred and twenty-four patients who were diagnosed with IgA nephropathy in West China Hospital of Sichuan University were selected as the study subjects. The baseline data were recorded. All patients were followed up for 3 years. Patients with poor prognosis were defined as poor prognosis group, and the patient with no adverse prognosis was defined as a good prognosis group during the follow-up period. The risk factors that may affect the prognosis of patients with IgAN were analyzed by single factor analysis. The influence of all factors that were statistically significant on the prognosis of the patients was further evaluated by multifactor Cox regression. The single factor analysis and multivariate Cox proportional hazard model showed that patients with 24 h urinary protein, pathological type, Oxford classification (T1+T2), Lee (grade IV) and mesangial IgM deposition were independent factors of patients, and the difference was statistically significant, their P-values were 0.041, 0.046, 0.037, 0.043, and 0.028, respectively. Patients with 24 h urinary protein, pathological type, Oxford classification (T1+T2), Lee (grade IV) and mesangial IgM deposition can be used as independent factors affecting poor prognosis in primary IgAN patients. It provides evidence for early detection of high-risk IgA nephropathy.

Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children

“…We found by Cox regression that interstitial brosis and IgA deposition strength were the independent risk factors for IgAVN, and interstitial brosis was a risk factor for IgAN. Interstitial brosis is a signi cant factor in uencing kidney outcomes under the comprehensive comparison [30][31][32][33]. In addition, our study discovered that cellular crescents in IgAVN were more common in glomerular lesions, suggesting an acute course of kidney lesions in IgAVN.…”

Albumin-to-fibrinogen ratio is an independent predictor of corticosteroid response and prognosis in patients with IgA nephropathy

“…Various studies have indicated various prognostic parameters of IgAN. For example, proteinuria, serum creatinine, and Oxford classification indices were considered risk factors for the early diagnosis of IgAN [ 19 ]. Moreover, some other new indicators also have excellent prognostic predictive ability in IgAN patients, e.g.…”

Association between geriatric nutritional risk index and pathological phenotypes of IgA nephropathy

“…Because GNRI can reflect the status of nutrition and inflammation, this may impact the synthesis of hemoglobin. Serum creatinine, eGFR, proteinuria and the Oxford classification are generally used for the diagnosis and classification of IgAN ( Hao et al, 2019 ). This study did not find that the GNRI scores were related to serum creatinine and eGFR as calculated, but they were related to histological lesions.…”