Analysis of the Radiocardiogram in Heart Failure

Shipley, Reginald A.; Clark, Richard E.; Liebowitz, Daniel; Krohmer, Jack S.

doi:10.1161/01.res.1.5.428

Cited by 40 publications

(15 citation statements)

References 11 publications

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“…Hakkila and Pietilk (8) and Eich, Chaffee, and Chodos (10) found values for the peak-to-peak time similar to those reported by Shipley, Clark, Liebowitz, and Krohmer (30), which are approximately 30%v higher than the PMTT of 4.6 seconds found in the present series. As Eich and associates point out, the volume measured on the basis of the peak-to-peak time includes blood contained in both sides of the heart.…”

Section: Discussionsupporting

confidence: 90%

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

Giuntini¹,

Lewis²,

Luís³

et al. 1963

J. Clin. Invest.

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Determination of the pulmonary blood volume, as distinguished from the central blood volume, has been hampered by the inaccessibility of the outflow of the pulmonary circulation to sampling. Recently, this difficulty has been circumvented by combined catheterization of the right and left hearts, which allows calculation of pulmonary mean transit time from arterial dilution curves obtained by injection of label into the pulmonary artery and left atrium (1-4). The information thus obtained provides the best available estimate of pulmonary blood volume but is restricted to a relatively small group of patients.A different approach is provided by external counting techniques. Double-peaked curves, named radiocardiograms (5), are obtained by injecting a gamma-emitting label into either a peripheral vein, the right atrium, or the right ventricle, and monitoring its dilution in the cardiac cavities with a scintillation detector collimated over the precordium. It is possible, in most instances, to separate completely the right and left components of radiocardiograms; thus two dilution curves, respectively upstream and downstream to the pulmonary circulation, can be obtained (Figure 1). However, these precordial curves cannot be considered as ordinary dye-dilution curves, since their characteristics depend on the contributions of several circulatory sections. This is particularly true for the left component of radiocardiograms, which, with the type of collimator commonly used, is due, before the time of intracardiac recirculation,

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Section: Discussionsupporting

confidence: 90%

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

Giuntini¹,

Lewis²,

Luís³

et al. 1963

J. Clin. Invest.

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“…The standard deviation of a single determination by any of these methods was estimated to be ± 0.25 L./min./M. 2 As shown in table 2, duplicate precordial determinations did not differ any more than expected on the basis of the precision of the methods. The estimated standard deviation between duplicate determinations was ± 0.25 L./min./M.…”

Section: Resultsmentioning

confidence: 70%

“…2 (standard error of the difference 0.08 based on the differences between the two methods in each instance). In 25 instances in which all the parameters could be compared, the mean values were 2.97, 2.91, and 3.01 L./min./M.…”

Section: Resultsmentioning

confidence: 99%

“…In 25 instances in which all the parameters could be compared, the mean values were 2.97, 2.91, and 3.01 L./min./M. 2 for the precordial, arterial, and Fick methods respectively, (standard error of the difference 0.07 based on the differences among the three methods in each instance). There was no evidence that the precision differed from one method to another.…”

Section: Resultsmentioning

confidence: 99%

“…At a sampling interval of 2 sec, the latter peak values represented 1,000 to 3,000 actual counts. Shipley 2 and Veall 3 present the mathematical validity of modifications of the Stewart-Hamilton 596 SCHREINER, LOVE JOY, YU equation to include dilution curves having a double rise. It is thus assumed that at equilibrium the observed radiation intensity (representing concentration) is the sum of the components which had caused the double rise (i.e., those derived from the pulmonary artery and from the aorta).…”

Section: Methodsmentioning

confidence: 99%

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Estimation of Cardiac Output from Precordial Dilution Curves in Patients with Cardiopulmonary Disease

Schreiner

Lovejoy

et al. 1959

Circulation Research

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Comparison of flow rates measured from precordial dilution curves, simultaneous direct arterial dilution curves, and nearly simultaneous Fick determinations in 29 patients failed to indicate any difference in precision. Successive precordial determinations of flow rate were adequately reproducible. It is concluded that the precordial dilution method gives flow values comparable to those obtained by other, more laborious methods.

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Quantitative radionuclide angiocardiography

Scholz¹,

Rerych²,

Moran³

et al. 1980

Cathet. Cardiovasc. Diagn.

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This study introduces a new method for calculating actual left ventricular volumes and cardiac output from data recorded during a single transit of a radionuclide bolus through the heart, and describes in detail current radionuclide angiocardiography methodology. A group of 64 healthy adults with a wide age range were studied to define the normal range of hemodynamic parameters determined by the technique. The normal radionuclide cardiac index averaged 3.25 +/- 0.75 liters/min/m2, the end-diastolic volume index was 62 +/- 16 ml/m2, the stroke volume index was 40 +/- 9 ml/m2, and the ejection fraction was 0.66 +/- 0.07. Radionuclide angiocardiograms were performed in patients undergoing cardiac catheterization to validate the measurements. In 33 patients studied by both techniques on the same day, a close correlation was documented for measurement of ejection fraction (r = 0.89) and end-diastolic volume (r = 0.89). Determination of the linear regression equation for the end-diastolic volumes obtained by the two methods (EDVcath = 1.26 x EDVRN - 7.56) permitted correction of end-diastolic volume and provided an approach for calculation of stroke volume and cardiac output. To validate the method of volumetric cardiac output calculation, 33 simultaneous radionuclide and indocyanine green dye determinations of cardiac output were performed in 18 normal young adults and correlated closely over a range of 4-17 liters/min (r = 0.94). These independent comparisons of radionuclide measurements with two separate methods document that initial transit radionuclide angiocardiography accurately assesses left ventricular function.

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Analysis of the Radiocardiogram in Heart Failure

Cited by 40 publications

References 11 publications

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

Estimation of Cardiac Output from Precordial Dilution Curves in Patients with Cardiopulmonary Disease

Quantitative radionuclide angiocardiography

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