Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome

Yang, Rui; Gao, Chang; Yan, Yizhi; Huang, Yongle; Wang, Jianli; Zhang, Chunmei; Ma, Xiuli; Li, Nannan; Du, Xiaoguo; Zhang, Liqiang; Wang, Ying; Li, Rong; Qiao, Jie

doi:10.1007/s11325-021-02376-2

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…OSA is recognized to be associated with endocrine dysfunction and hypothalamic-pituitary-gonadal axis disorders, 2 and OSA is more prone to occur in males or postmenopausal females, substantiating the probable association with sex hormones. 18 Several previous studies have shown that males with OSA have lower serum testosterone levels 3,19 and decreased SHBG levels, 20 whereas females with OSA have elevated 21 or equivalent 19 serum testosterone levels and lower SHBG levels. 22 Likewise, our research observed a decrease in SHBG, TT, and BioT in males, and a decrease in SHBG with an increase in BioT in females with OSA, which underscore the complex interplay of these endocrine mediators.…”

Section: Discussionmentioning

confidence: 98%

“…Notably, OSA patients tend to have lower levels of HDL-C and ApoA1, markers commonly associated with high cardiovascular risk, 3,21,[33][34][35][36][37][38] but high levels of HDL-C and low levels of ApoA1 have been associated with an increased risk of T2DM. 39,40 Our MR analysis revealed a consistent trend amongst patients with OSA, in which they exhibited reduced levels of HDL-C and ApoA1.…”

Section: Discussionmentioning

confidence: 99%

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How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study

Shen,

Wang,

Zhang

et al. 2023

NSS

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Background Obstructive sleep apnea (OSA), high blood pressure (HBP), and type 2 diabetes mellitus (T2DM) have a close clinical relationship, but whether and how OSA affects HBP and T2DM is unclear. Study Design and Methods Two-step, two-sample Mendelian randomization techniques were applied using single-nucleotide polymorphisms as genetic instruments for exposure and mediators, thus minimizing bias due to confounding factors and reverse causality. The total effect of OSA on HBP and T2DM was categorized into direct and mediating effects based on the mediating factors. Results Two-sample MR analysis showed that OSA increased the risk of HBP (odds ratio [OR] = 1.010, 95% confidence interval [CI], 1.002–1.018; P = 0.0121) and T2DM (OR = 1.140, 95% CI, 1.059–1.228; P = 0.0005). In the process of OSA caused by HBP, sex hormone-binding globulin (SHBG) (female, 4.47% mediation; male, 2.76% mediation), total testosterone (TT) (male, 3.72% mediation), bioavailable testosterone (BioT) (female, 7.74% mediation), high-density lipoprotein cholesterol (HDL-C) (3.25% mediation), and apolipoprotein A1 (ApoA1) (1.31% mediation) were individual contributors. SHBG (female, 4.10% mediation; male, 1.58% mediation), TT (male, 3.69% mediation), BioT (female, 2.58% mediation), HDL-C (3.32% mediation), ApoA1 (2.14% mediation), and omega-6 fatty acids (2.33% mediation) may have mediating roles to varying degrees in the process of OSA caused by T2DM. Interpretation This MR study showed that OSA is a risk factor for HBP and T2DM, and the evaluation of mediators may help further reveal the specific mechanism by which OSA causes HBP and T2DM.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study

Shen,

Wang,

Zhang

et al. 2023

NSS

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“…Over the last two decades, the majority of observational studies that investigated the prevalence of sleep problems in reproductive-aged women with PCOS were from cohort or case-control studies and only two were longitudinal studies. Out of these studies, n ¼ 10 examined the presence of OSA, SDB, or sleep apnea only, 63,[65][66][67]72,73,78,79,82,125 while others (n ¼ 13) have included sleep disorders such as insomnia, circadian rhythm disorders, and/or sleep disturbances like EDS. 37,38,61,62,64,70,[74][75][76][77]112,117,119 Eight studies focused on examining sleep disturbances (i.e., sleep difficulties, short sleep, and/or poor sleep quality), but not clinical sleep disorders in PCOS.…”

Section: Prevalencementioning

confidence: 99%

Beyond Counting Sheep: Exploring the Link between Polycystic Ovary Syndrome and Sleep Health

Jafar,

Bennett,

Moran

et al. 2023

Semin Reprod Med

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Polycystic ovary syndrome (PCOS) is a common hormonal condition with reproductive, metabolic, and psychological sequelae that affects 8 to 13% of reproductive-aged women and 3 to 11% of adolescent girls. Sleep is often compromised in women with PCOS due to increased rates of sleep problems, with the most established problem being obstructive sleep apnea (OSA). OSA is highly prevalent in reproductive-aged adult women with PCOS, but not so in adolescence. The international evidence-based PCOS guideline to improve health outcomes in women with PCOS indicated routine screening to identify and alleviate symptoms of OSA. The guidelines, however, did not weigh other multidimensional constructs of sleep health such as sleep disturbances (e.g., sleep quality and quantity), beyond OSA. This is perhaps due to the lack of research and existing mixed findings in the area of PCOS and sleep health. This narrative review summarizes the current knowledge about OSA and expands further to include the limited knowledge about other sleep problems in PCOS among reproductive-aged women and adolescent girls. We broadly cover the prevalence, risk factors, and mechanisms of sleep problems in PCOS and their relationship with cardiometabolic and psychological health. A brief summary on treatment and intervention strategies for sleep problems in PCOS and future recommendations will be deliberated.

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Dermatologic Changes Related to Patients with Obstructive Sleep Apnea

Redondo

2023

Obstructive Sleep Apnea

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Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome

Cited by 9 publications

References 30 publications

How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study

How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study

Beyond Counting Sheep: Exploring the Link between Polycystic Ovary Syndrome and Sleep Health

Dermatologic Changes Related to Patients with Obstructive Sleep Apnea

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