In this paper, the performance is analyzed for the P1–p2–n and N1–n2–p hetero‐ and homojunction GaSb/Ga0.8In0.2As0.19Sb0.81 photodetectors operated at 300 K, based on the incident wavelength and the parameters of GaSb and Ga0.8In0.2As0.19Sb0.81. The analyzed results show that the detectivity is much higher with the light incident first through the p‐type than first through the n‐type Ga0.8In0.2As0.19Sb0.81 for both structures. In addition, the carrier concentration of GaSb should be as low as possible to reduce the tunneling noise through the P1–p2 and N1–n2 heterojunctions. With the same condition for the two structures, the N1–n2–p structure is more advantage than the P1–p2–n structure because the high P1–p2 heterojunction recombination velocity increases the Auger and radiative noise mechanisms, which limit the performance of photodetectors.