This study documented the wild plants used by Tibetans and the related traditional knowledge in Burang Town (Karnali River Valley). Ethnobotanical surveys, including semi-structured interviews and participatory observations, were conducted in five Tibetan communities in July 2020 and August 2021. The informant consensus factor (ICF) and cultural importance index (CI) were used for data analyses. In total, 76 wild species belonging to 58 genera and 30 families were determined to be used. These included 26 edible, 29 medicinal, 34 fodder, 21 fuel, 17 incense, three economic, three dye, two ritual, two handicraft, and one species for tobacco plants species; many of these have multiple uses. The top five important plants are Carum carvi (CI = 1.88), Hippophae tibetana (CI = 1.45), Rheum moorcroftianum (CI = 0.87), Urtica dioica (CI = 1.45) and Chenopodium album (CI = 0.75). Of the wild plant species used, 53 were recorded in croplands and 25 were found in alpine pastures. This pattern of use is influenced by local livelihood patterns and culture. Plants in highland cropland have diverse ethnobotanical values that are often overlooked. These findings will inform strategies and plans for local communities and governments to sustainably use and protect plants at high altitudes.