Analysis of the Nano-Kinetic Movement of a Single DNA by a Pin-Fiber Video Scope

Hirakawa, Yasuyuki; Suzutoh, Masashi; Ohnishi, Hitoshi; Shingaki, Tomoteru; Eyring, Edward M.; Tokunaga, Makio; Masujima, Tsutomu

doi:10.2116/analsci.18.1293

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“…We named this system pin-fiber video scope (PFVS), and a prototype PFVS system was fabricated. 7 We have already reported observations of gold colloidal particles and living cells by this system. 8 In these reports, we confirm that this newly developed video microscope system has the potential to be a superior device for biological and biomedical applications.…”

Section: Introductionmentioning

confidence: 91%

Observation and analysis of single DNA nano-kinetics by pin-fiber video scope

Hirakawa

Suzuto

Ohnishi

et al. 2003

Analyst

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The nano-kinetic movement of a single DNA molecule was observed and analyzed by a newly developed video-microscope system with an optical fiber, called a pin-fiber video scope. A single lambda-DNA molecule was put in focus using fiber-illumination, and the stretching and shrinking motion was measured. The molecule's kinetics were analyzed by numerical calculations and are discussed. A photocleavage phenomenon of DNA molecules was also visualized by the pin-fiber video scope. The new video-microscope system has the potential to observe and analyze the nano-kinetics of a single molecule.

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Section: Introductionmentioning

confidence: 91%