Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus)

doi:10.37506/ijfmt.v14i3.10695

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“…The results of the present study indicate that the leaf and seed extracts of M. oleifera have a reducing effect on glucose levels (i.e., antihyperglycemic or antidiabetic) in alloxaninduced diabetic mice. Therefore, this result confirms the antihyperglycemic properties of M. oleifera as previously reported by several researchers [58,89,105,108]. Many studies have reported the positive effects of herbal medicines in the management of diabetes owing to their content of bioactive phytochemicals that are frequently implicated as having an antidiabetic effect [132,133].…”

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confidence: 90%

“…12 Oxidative Medicine and Cellular Longevity treat diabetes [84][85][86][87]. Numerous studies have reported the antidiabetic (hypoglycemic) properties of M. oleifera leaf extract [88][89][90][91][92][93][94][95][96][97][98][99], seed extract [100][101][102][103][104][105][106][107][108], root extract [109,110], pod extract [57,111], fruit extract [19,112], and flower extract [113,114]. The hypoglycemic effect of the leaf, seed, root, pod, fruit, and flower of M. oleifera extracts was variable in the experimental animal models of induced diabetes, according to the dose and duration of treatment.…”

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confidence: 99%

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Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study

Aljazzaf,

Regeai,

Elghmasi

et al. 2023

Oxidative Medicine and Cellular Longevity

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Moringa oleifera (Moringaceae) is a medicinal plant rich in biologically active compounds. The aim of the present study was to screen M. oleifera methanolic leaf (L) extract, seed (S) extract, and a combined leaf/seed extract (2L : 1S ratio) for antidiabetic and antioxidant activities in mice following administration at a dose level of 500 mg/kg of body weight/day. Diabetes was induced by alloxan administration. Mice were treated with the extracts for 1 and 3 months and compared with the appropriate control. At the end of the study period, the mice were euthanized and pancreas, liver, kidney, and blood samples were collected for the analysis of biochemical parameters and histopathology. The oral administration of the combined L/S extract significantly reduced fasting blood glucose to normal levels compared with L or S extracts individually; moreover, a significant decrease in cholesterol, triglycerides, creatinine, liver enzymes, and oxidant markers was observed, with a concomitant increase in antioxidant biomarkers. Thus, the combined extract has stronger antihyperlipidemic and antioxidant properties than the individual extracts. The histopathological results also support the biochemical parameters, showing recovery of the pancreas, liver, and kidney tissue. The effects of the combined L/S extracts persisted throughout the study period tested. To the best of our knowledge, this is the first study to report on the antidiabetic, antioxidant, and antihyperlipidemic effects of a combined L/S extract of M. oleifera in an alloxan-induced diabetic model in mice. Our results suggest the potential for developing a natural potent antidiabetic drug from M. oleifera; however, clinical studies are required.

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confidence: 90%