Analysis of the metabolic mechanism in Cantharidin-induced hepatotoxicity in LO2 cells using lipidomics analysis

Zhang, Jianyong; Liu, Fang; He, TianMu; Wang, QiYi; Zhang, Yan; Yuan, Xiaoyan; Li, Xiaofei; Duan, CanCan

doi:10.53388/atr20210503

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“…Zhou et al (2019) assessed the toxic effects of As 4 S 4 with lipidomics and revealed that the lipidomic profiling was significantly changed after oral exposure to arsenic. Zhang et al (2021) discovered that cantharidin showed cytotoxicity on human liver LO2 cells using lipidomics. The toxicological mechanism was related to the disorder of triglyceride and acylcarnitine metabolism.…”

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confidence: 99%

Hepatic effect of subacute Fe₂O₃ nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

Ren

Shao

Liu

et al. 2023

Biomedical Chromatography

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Fe 2 O 3 nanoparticles (Fe 2 O 3 NPs) are one of the components of food additives numbered E172 and have been widely used as food pigments to color sweets. Although a large number of studies have reported that Fe 2 O 3 NPs could induce hepatotoxicity, the pathogenesis is still unclear, especially the subacute effects on the metabolic network after oral exposure. Therefore, it is necessary to define a highly sensitive strategy to investigate the potential effects of Fe 2 O 3 NPs and the mechanism. In this study, an animal experiment showed that Fe 2 O 3 NPs had no obvious toxic effects on body weight, histopathology and oxide stress. In order to further investigate the potential effects of Fe 2 O 3 NPs in vivo, a more sensitive LC-MS/MS-based lipidomic study was performed. The results of multivariate statistical analysis and western blot analysis showed that Fe 2 O 3 NP exposure significantly affects the hepatic glycerophospholipid metabolism, decreasing triacylglycerol, diglyceride, lysophosphatidylethanolamine and free fatty acids, and increasing phosphatidylcholine, lysophosphatidylinositol and coenzyme Q9. These data provide further insight into the hepatic subacute effects of Fe 2 O 3 NPs obtained by conventional toxicology methods.

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Section: Introductionmentioning

confidence: 99%

Hepatic effect of subacute Fe₂O₃ nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

Ren

Shao

Liu

et al. 2023

Biomedical Chromatography

View full text Add to dashboard Cite

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Analysis of the metabolic mechanism in Cantharidin-induced hepatotoxicity in LO2 cells using lipidomics analysis

Cited by 1 publication

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Hepatic effect of subacute Fe₂O₃ nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

Hepatic effect of subacute Fe₂O₃ nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

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Analysis of the metabolic mechanism in Cantharidin-induced hepatotoxicity in LO2 cells using lipidomics analysis

Cited by 1 publication

References 0 publications

Hepatic effect of subacute Fe2O3 nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

Hepatic effect of subacute Fe2O3 nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

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Hepatic effect of subacute Fe₂O₃ nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics

Hepatic effect of subacute Fe₂O₃ nanoparticles exposure in Sprague–Dawley rats by LC–MS/MS based lipidomics