Analysis of the mechanical response of biomimetic materials with highly oriented microstructures through 3D printing, mechanical testing and modeling

Obaldia, Enrique Escobar de; Jeong, C.H.; Grunenfelder, Lessa Kay; Kisailus, David; Zavattieri, Pablo

doi:10.1016/j.jmbbm.2015.03.026

Cited by 56 publications

(23 citation statements)

References 77 publications

(114 reference statements)

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“…With the help of the printing platform technology, “core-shell” cell fiber structures can be fabricated layer-by-layer with predesigned shape. The shell has sufficient strength to serve as a scaffold and the core is soft which is beneficial for cell survival 28 . This superior biological structure lays the foundation for its applications, such in as tissue engineering and as drug release platforms 29 .…”

Section: Discussionmentioning

confidence: 99%

Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers

Dai

Liu

Ouyang

et al. 2017

Sci Rep

116

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Three-dimensional (3D) bioprinting of living structures with cell-laden biomaterials has been achieved in vitro, however, some cell-cell interactions are limited by the existing hydrogel. To better mimic tumor microenvironment, self-assembled multicellular heterogeneous brain tumor fibers have been fabricated by a custom-made coaxial extrusion 3D bioprinting system, with high viability, proliferative activity and efficient tumor-stromal interactions. Therein, in order to further verify the sufficient interactions between tumor cells and stroma MSCs, CRE-LOXP switch gene system which contained GSCs transfected with “LOXP-STOP-LOXP-RFP” genes and MSCs transfected with “CRE recombinase” gene was used. Results showed that tumor-stroma cells interacted with each other and fused, the transcription of RFP was higher than that of 2D culture model and control group with cells mixed directly into alginate, respectively. RFP expression was observed only in the cell fibers but not in the control group under confocal microscope. In conclusion, coaxial 3D bioprinted multicellular self-assembled heterogeneous tumor tissue-like fibers provided preferable 3D models for studying tumor microenvironment in vitro, especially for tumor-stromal interactions.

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Section: Discussionmentioning

confidence: 99%

Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers

Dai

Liu

Ouyang

et al. 2017

Sci Rep

116

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“…In refs. the authors used this approach to study the rod‐like microstructure found in the Cryptochiton stelleri radular teeth, elucidating the effect of geometrical features like orientation, volume fraction, and rod aspect ratio on the overall mechanical response ( Figure a–c). In this work, experimental results demonstrated that alignment rod‐like microstructures present a higher contact resistance and stiffness compared with randomly distributed fibrous materials.…”

Section: Multiscale Modelingmentioning

confidence: 99%

“…i) Results from finite element simulations show redistribution of the von Mises stress in the Bouligand structure compared with the herringbone pattern. a,b‐right) Adapted with permission . Copyright 2015, Elsevier.…”

Section: Multiscale Modelingmentioning

confidence: 99%

Multiscale Toughening Mechanisms in Biological Materials and Bioinspired Designs

et al. 2019

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Biological materials found in Nature such as nacre and bone are well recognized as light-weight, strong, and tough structural materials. The remarkable toughness and damage tolerance of such biological materials are conferred through hierarchical assembly of their multiscale (i.e., atomicto macroscale) architectures and components. Herein, the toughening mechanisms of different organisms at multilength scales are identified and summarized: macromolecular deformation, chemical bond breakage, and biomineral crystal imperfections at the atomic scale; biopolymer fibril reconfiguration/deformation and biomineral nanoparticle/nanoplatelet/ nanorod translation, and crack reorientation at the nanoscale; crack deflection and twisting by characteristic features such as tubules and lamellae at the microscale; and structure and morphology optimization at the macroscale. In addition, the actual loading conditions of the natural organisms are different, leading to energy dissipation occurring at different time scales. These toughening mechanisms are further illustrated by comparing the experimental results with computational modeling. Modeling methods at different length and time scales are reviewed. Examples of biomimetic designs that realize the multiscale toughening mechanisms in engineering materials are introduced. Indeed, there is still plenty of room mimicking the strong and tough biological designs at the multilength and time scale in Nature.

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“…This process is also difficult to be controlled and the porous structure is more likely inhomogeneous. Recent years, 3D printing has been a quite popular method for fabricating biomaterials [15][16][17]. When this method was used to fabricate porous titanium [18,19], the metallurgical problems involved in the processing, such as impurity containment and metallurgical defects, might severe deteriorate the mechanical properties, which needs further investigations.…”

Section: Introductionmentioning

confidence: 99%

In-situ formed graded microporous structure in titanium alloys and its effect on the mechanical properties

2015

Materials & Design

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Analysis of the mechanical response of biomimetic materials with highly oriented microstructures through 3D printing, mechanical testing and modeling

Cited by 56 publications

References 77 publications

Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers

Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers

Multiscale Toughening Mechanisms in Biological Materials and Bioinspired Designs

In-situ formed graded microporous structure in titanium alloys and its effect on the mechanical properties

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