Analysis of the Ki‐67 antigen at the invasive tumour front of human oral squamous cell carcinoma

Tumuluri, Vijay; Thomas, G.A.; Fraser, Ian S.

doi:10.1034/j.1600-0714.2002.00042.x

Cited by 76 publications

(85 citation statements)

References 26 publications

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“…It was found that the mean value of Ki-67 LI in grade I (47.8%) was double than that of grade III (88.0%) and grade II (73.2%) having an intermediate value between the two, thus marking a clear-cut difference in the mean value in different grades (p = 0.000; Table 1). These results are consistent with Tumuluri et al, 19 Kurokawa et al, 20 Tumuluri et al, 21 and Premlatha and Uma. 22 Thus, the assessment of cell proliferation in various types of tumors may prove to be an important adjunct to histologically based tumor classification.…”

Section: Discussionsupporting

confidence: 83%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:The aim of the study was to evaluate the proliferative index (PI) at their invasive front of oral cancer and their association with Bryne's grades of oral squamous cell carcinoma (OSCC) and compare the PI with lymph node metastasis, site of involvement, and habits. Materials and methods:The Ki-67 antigen expression was immunohistochemically evaluated in a total of 102 cases that included the histopathologically diagnosed archival specimens of OSCCs. They were subdivided by Bryne's histopathological grading into grade I (40 cases), grade II (32 cases), and grade III (30 cases). The nucleus with brown stain was considered positive. Cells were counted under 400× magnification. The proliferative activity thus determined was then expressed as a percentage of Ki-67 labeling index (Ki-67 LI) positive cells. Results:A stepwise increase in the mean Ki-67 LI was found from grade I to III squamous cell carcinoma, thus correlating with the histological grading. In addition, there was a higher PI seen in cases associated with metastatic lymph node, which concords with the higher biologic aggressiveness and poor prognosis of the lesion. Conclusion:The present study shows a definitive correlation of Ki-67 antigen with the Bryne's histological grading, all the parameters of Bryne's grading for OSCC and lymph node status of the patient proving its association as an effective tool to grade the tumors and finally read the prognosis of the tumor. Clinical significance: Cell proliferation is regarded as one of the most important biologic mechanisms in oncogenesis. The role of cell proliferation in tumor progression has been inferred in studies concerned with human cancer by comparing the PI of normal tissue, preneoplastic and neoplastic lesions. The Ki-67 antigen-labeled cells can prove to be an effective aid to grade the tumors. It might be possible to standardize and objectify tumor grading among pathology laboratories. Proliferative Index in Invasive Tumor

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Section: Discussionsupporting

confidence: 83%

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Bhuyan¹,

Sarangi²,

Das³

et al. 2018

The Journal of Contemporary Dental Practice

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“…The highest Ki-67 expression was found in poorly differentiated squamous cell carcinoma. Also, findings of studies Tumuluri et al 19 21 (2010) were showing concordance with the finding of the present study where increasing trend of mean Ki-67 LI was observed with the increasing histopathological grades of oral squamous cell carcinoma.…”

Section: Discussionsupporting

confidence: 81%

Histopathological Grading of Oral Squamous Cell Carcinoma and Its Correlation With Ki-67 - A Proliferative Marker

Chaudhari¹,

Shukla²,

Tamhane³

et al. 2018

jebmh

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BACKGROUNDThe prognosis of squamous cell carcinoma depends on the size of the lesion, level of local invasion, lymphatic spread, and presence of distant nodal metastases. The behaviour of the squamous cell carcinoma is marked by the degree of cell proliferation and differentiation, histopathological grading and proliferative index which can be derived by measuring Ki-67-an immunohistochemical marker.

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“…Many studies showed the detection of Ki67 antigen provided a significant information about degree of aggressiveness and prognosis of OSCC (Tumuluri et al, 2002;2004;Kurokawa et al, 2005). But, relatively few studies have investigated Ki67 expression in VC and its comparison with SCC, particularly focused on the oral cavity cases (Drachenberg et al,1997 ;Theegarten et al, 1997 ;Saito et al,1999 ;Adegboyega et al,2005 ;Stankiewicz et al,2009 ).…”

Section: Assessment Of Cellular Proliferation In Oral Verrucousmentioning

confidence: 99%

Assessment of Cellular Proliferation in Oral Verrucous Carcinoma and Well-Differentiated Oral Squamous Cell Carcinoma Using Ki67: A Non-Reliable Factor for Differential Diagnosis?

Zargaran¹,

Eshghyar²,

Baghaei³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Analysis of the Ki‐67 antigen at the invasive tumour front of human oral squamous cell carcinoma

Abstract: It was concluded from this study that cell proliferation (as measured by the Ki-67 antigen) at the ITF had a strong positive relationship with histological grading in human oral SCC.

Cited by 76 publications

References 26 publications

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Proliferative Index in Invasive Tumor Front of Oral Squamous Cell Carcinoma: A Potential Prognostic Indicator

Histopathological Grading of Oral Squamous Cell Carcinoma and Its Correlation With Ki-67 - A Proliferative Marker

Assessment of Cellular Proliferation in Oral Verrucous Carcinoma and Well-Differentiated Oral Squamous Cell Carcinoma Using Ki67: A Non-Reliable Factor for Differential Diagnosis?

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