Analysis of the inhibitory mechanism of d-allose on MOLT-4F leukemia cell proliferation

Hirata, Yuko; Saito, Madoka; Tsukamoto, Ikuko; Yamaguchi, Fuminori; Sui, Li; Kamitori, Kazuyo; Dong, Yan; Uehara, Eisuke; Konishi, Ryoji; Janjua, Najma A.; Tokuda, Masaaki

doi:10.1016/j.jbiosc.2008.12.021

Cited by 32 publications

(23 citation statements)

References 17 publications

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“…The growth inhibitory activity of Glc-C12 (57%) was significantly lower than that of 3, and 100 μM of dodecanoic acid (lauric acid) had little effect (data not shown). Since it has previously been reported that Dglucose had little effect on the proliferation of MOLT-4F cells, even at 20 mM, 4) these results indicate that the D-allose moiety was important for this inhibitory activity. GI 50 values, the concentration required to inhibit cell growth by 50%, estimated from dose-response curves are listed in 14) However, the inhibitory effects of D-allose ethers were about 5-100-fold weaker than those of the corresponding D-glucose ethers.…”

Section: )supporting

confidence: 49%

“…4) MOLT-4F cells were incubated for 48 h with various concentrations of each compound (10, 30, 100, and 300 μM for 1, 2, 3, and Glc-C12; 100, 300, 1000, and 3000 μM for D-allose), and the cell viability was measured as previously described. 4) Cell growth was calculated as a percentage of the untreated control (see the legend to Fig. 2 for details).…”

Section: )mentioning

confidence: 99%

“…Notes: Values are the mean, and error bars represent 95% confidence intervals (n = 3-12). The assay was performed under the conditions described by Hirata et al 4 ) A DMSO stock of the compounds was diluted with the assay medium to a final DMSO concentration of 0.5%. Cell growth was estimated using Cell-counting Kit 8 (Doujin Chemical, Kumamoto, Japan).…”

Section: )mentioning

confidence: 99%

“…D-Allose has been reported to have no effect on normal human cell lines, 2,9) but inhibited the proliferation of human ovarian, 1) prostate, 2) liver, 3) leukemia, 4) and tongue 10) cancer cell lines. D-Allose may therefore be a potential anti-cancer compound with few side effects.…”

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confidence: 99%

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Anti-proliferative activity of 6-O-acyl-d-allose against the human leukemia MOLT-4F cell line

Yanagita

Kobashi

Ogawa

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Section: )supporting

confidence: 49%

Section: )mentioning

confidence: 99%

Section: )mentioning

confidence: 99%

mentioning

confidence: 99%

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Anti-proliferative activity of 6-O-acyl-d-allose against the human leukemia MOLT-4F cell line

Yanagita

Kobashi

Ogawa

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…Analysis of the function of D-psicose ; Hossain et al, 2011, Miyanishi et al, 2008, Suna et al, 2007, Murao et al, 2007 Analysis of the function of D-allose ; Yamada et al, 2012, Kajikawa et al, 2010, Hirata et al, 2009, Mitani et al, 2009, Sui et al, 2007 On the other hand, these are few papers analyzed by the viewpoint from consumers. The Rare Sugars is good for the health and is sold in the market as a sweetening, seasoning or functional ingredient for food.…”

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confidence: 99%

Correspondence Analysis for the Questionnaire Investigation on Rare Sugars

Higuchi¹,

Takeyasu²,

Takeyasu³

2017

BMR

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The Rare Sugars exist naturally and have many kinds (more than 50). They have good effect for health such as prevention of increasing a blood-sugar level after eating, suppression of fat accumulation, suppression of increasing the blood pressure, and antioxidative effect etc. It is in the spotlight for many people especially for those who are in the metabolic syndrome. There are few related papers concerning the marketing research and its utilization of this matter. In this paper, a questionnaire investigation is executed in order to clarify consumers' current condition and their consciousness, and to seek the possibility of utilizing the rare sugars. Correspondence Analysis was executed based on that. 5 clusters could be confirmed in the "Common part + Positive part" analysis. We could also confirm 3 clusters in the "Common part + Negative part" analysis. We could grasp the relation among questions group on the whole. Mathematics Subject Classification: 62H15

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Both Ser361 phosphorylation and the C‐arrestin domain of thioredoxin interacting protein are important for cell cycle blockade at the G1/S checkpoint

et al. 2018

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Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down‐regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH‐7. TXNIP contains putative phosphorylation sites, but the effects of its phosphorylation have not been fully characterized. TXNIP also contains two α‐arrestin domains (N‐arrestin and C‐arrestin) whose functions are not fully understood. Here, we reveal an association between TXNIP and cell cycle regulatory proteins (p27 kip1 , Jun activation domain‐binding protein 1 (JAB1), Cdk2, and cyclin E), suggesting its participation in cell cycle regulation. We observed phosphorylation of TXNIP and used both in vivo and in vitro kinase assays to demonstrate that TXNIP can be phosphorylated by p38 mitogen‐activated protein kinase. Furthermore, we also identified Ser361 in TXNIP as one of the major phosphorylation sites. Cell cycle analysis showed that Ser361 phosphorylation participates in TXNIP‐mediated cell cycle arrest. In addition, the C‐arrestin domain may also play an important role in cell cycle arrest. We also showed that phosphorylation at Ser361 may be important for the association of TXNIP with JAB1 and that the C‐arrestin domain is necessary for the nuclear localization of this molecule. Collectively, these studies reveal that TXNIP participates in cell cycle regulation through association with regulatory proteins, especially JAB1, and that C‐arrestin‐dependent nuclear localization is important for this function. This work may facilitate the development of a new cancer therapy strategy that targets TXNIP as a key molecule inhibiting cancer cell growth via cell cycle blockade at the G1/S checkpoint.

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Analysis of the inhibitory mechanism of d-allose on MOLT-4F leukemia cell proliferation

Cited by 32 publications

References 17 publications

Anti-proliferative activity of 6-O-acyl-d-allose against the human leukemia MOLT-4F cell line

Anti-proliferative activity of 6-O-acyl-d-allose against the human leukemia MOLT-4F cell line

Correspondence Analysis for the Questionnaire Investigation on Rare Sugars

Both Ser361 phosphorylation and the C‐arrestin domain of thioredoxin interacting protein are important for cell cycle blockade at the G1/S checkpoint

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